Anaerobic Sepsis Due to Multidrug-Resistant Bacteroides fragilis: Microbiological Cure and Clinical Response with Linezolid Therapy

We describe the first reported case of anaerobic sepsis due to Bacteroides fragilis with simultaneous resistance to metronidazole, β-lactams, β-lactam/β-lactamase inhibitors, carbapenems, macrolides, and tetracyclines. Microbiological cure and clinical improvement was achieved with linezolid therapy...

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Veröffentlicht in:	Clinical infectious diseases 2005-04, Vol.40 (7), p.e67-e68
Hauptverfasser:	Wareham, D. W., Wilks, M., Ahmed, D., Brazier, J. S., Millar, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - therapeutic use Anti-Bacterial Agents - therapeutic use Bacteroides fragilis Bacteroides fragilis - physiology Bacteroides Infections - microbiology Drug Resistance, Multiple, Bacterial Female Humans Linezolid Microbial Sensitivity Tests Middle Aged Oxazolidinones - therapeutic use Sepsis - drug therapy Sepsis - microbiology
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Zusammenfassung:	We describe the first reported case of anaerobic sepsis due to Bacteroides fragilis with simultaneous resistance to metronidazole, β-lactams, β-lactam/β-lactamase inhibitors, carbapenems, macrolides, and tetracyclines. Microbiological cure and clinical improvement was achieved with linezolid therapy, an agent that may be useful for the treatment of multidrug-resistant anaerobic infections.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/428623