Reported Use of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Was Not Associated with Reduced Recurrence of Colorectal Adenomas

We did a secondary analysis of data from three large colorectal adenoma chemoprevention trials to assess the association between 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor use and reduced risk of recurrent colorectal adenomas. Reported use of HMG-CoA reductase inhibitors was...

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Veröffentlicht in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2005-04, Vol.14 (4), p.1026-1027
Hauptverfasser: WEI, Jeffrey T, MOTT, Leila A, BARON, John A, SANDLER, Robert S
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container_issue 4
container_start_page 1026
container_title Cancer epidemiology, biomarkers & prevention
container_volume 14
creator WEI, Jeffrey T
MOTT, Leila A
BARON, John A
SANDLER, Robert S
description We did a secondary analysis of data from three large colorectal adenoma chemoprevention trials to assess the association between 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor use and reduced risk of recurrent colorectal adenomas. Reported use of HMG-CoA reductase inhibitors was not associated with a reduced recurrence of colorectal adenomas, multiple adenomas, or advanced adenomas. Lack of statistical power from limited exposure to HMG-CoA reductase inhibitors might be responsible for the lack of association.
doi_str_mv 10.1158/1055-9965.EPI-03-0080
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source MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Adenoma - prevention & control
Biological and medical sciences
Colorectal Neoplasms - prevention & control
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Male
Medical sciences
Neoplasm Recurrence, Local - prevention & control
Randomized Controlled Trials as Topic
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
title Reported Use of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Was Not Associated with Reduced Recurrence of Colorectal Adenomas
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