Interconceptional antibiotics to prevent spontaneous preterm birth: A randomized clinical trial

Interconceptional antibiotics to prevent spontaneous preterm birth: A randomized clinical trial

We hypothesized that upper genital tract microbial infection associated with spontaneous preterm birth may precede conception. Our objective was to estimate if antibiotic administration during the interpregnancy interval in nonpregnant women with a previous preterm birth before 34 weeks' gestat...

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Veröffentlicht in:American journal of obstetrics and gynecology 2006-03, Vol.194 (3), p.617-623
Hauptverfasser: Andrews, William W., Goldenberg, Robert L., Hauth, John C., Cliver, Suzanne P., Copper, Rachel, Conner, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Anti-Bacterial Agents - therapeutic use
Antibiotics
Azithromycin - therapeutic use
Bacterial diseases
Bacterial diseases of the genital system
Biological and medical sciences
Double-Blind Method
Endometritis
Female
Gynecology. Andrology. Obstetrics
Human bacterial diseases
Humans
Infection
Infectious diseases
Medical sciences
Metronidazole - therapeutic use
Preconception Care
Pregnancy
Premature Birth - prevention & control
Prematurity
Preterm birth
Recurrence
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Beschreibung
Zusammenfassung:We hypothesized that upper genital tract microbial infection associated with spontaneous preterm birth may precede conception. Our objective was to estimate if antibiotic administration during the interpregnancy interval in nonpregnant women with a previous preterm birth before 34 weeks' gestational age would reduce the rate of spontaneous preterm birth in the subsequent pregnancy. Women with a spontaneous preterm birth
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2005.11.049