The cytokine gene polymorphisms in patients with chronic kidney graft rejection

Chronic allograft rejection remains an important cause of morbidity after kidney transplantation. The aim of the study was to examine the association between IL-2, IL-6 and TNF-α promoter polymorphisms and chronic kidney allograft rejection. The study included 64 patients with long-term stable graft...

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Veröffentlicht in:	Transplant immunology 2005-03, Vol.14 (1), p.49-52
Hauptverfasser:	Pawlik, A., Domanski, L., Rozanski, J., Florczak, M., Wrzesniewska, J., Dutkiewicz, G., Dabrowska-Zamojcin, E., Gawronska-Szklarz, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chronic Disease Chronic rejection Cytokine Cytokines - genetics Cytokines - metabolism Graft Rejection - genetics Graft Rejection - immunology Humans Interleukin-2 - genetics Interleukin-2 - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Kidney allograft Kidney Transplantation Polymorphism Polymorphism, Genetic Promoter Regions, Genetic Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Chronic allograft rejection remains an important cause of morbidity after kidney transplantation. The aim of the study was to examine the association between IL-2, IL-6 and TNF-α promoter polymorphisms and chronic kidney allograft rejection. The study included 64 patients with long-term stable graft function and 62 with chronic allograft nephropathy. Among patients with chronic allograft nephropathy a statistically significant prevalence of the IL-6 CC genotype associated with low IL-6 expression was observed ( p
ISSN:	0966-3274 1878-5492
DOI:	10.1016/j.trim.2004.12.004