A Room-Temperature Protocol for the Rhodium(I)-Catalyzed Addition of Arylboron Compounds to Sulfinimines
The addition of organoboronic acids to chiral sulfinimines proceeds under mild conditions at room temperature, using Rh(I) catalysis in the absence of external phosphine ligands. Clean reaction only occurs in the presence of water as a cosolvent. The sulfinamide adducts are formed with high diastere...
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| Veröffentlicht in: | Organic letters 2005-04, Vol.7 (8), p.1481-1484 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The addition of organoboronic acids to chiral sulfinimines proceeds under mild conditions at room temperature, using Rh(I) catalysis in the absence of external phosphine ligands. Clean reaction only occurs in the presence of water as a cosolvent. The sulfinamide adducts are formed with high diastereoselectivities, providing a convenient route to the synthesis of enantiomerically enriched chiral benzylic amines. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/ol050014f |