Expedient Synthesis and Design Strategies for New Peptoid Construction

Expedient Synthesis and Design Strategies for New Peptoid Construction

A range of peptoids can be prepared efficiently using microwave-assisted solid-phase chemistry in a commercial reactor. This method is most effective for the installation of electronically deactivated benzylic amines. The systematic incorporation of these amines into peptoids can deliver oligomers c...

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Veröffentlicht in:Organic letters 2005-04, Vol.7 (8), p.1521-1524
Hauptverfasser: Gorske, Benjamin C, Jewell, Sarah A, Guerard, Emily J, Blackwell, Helen E
Format: Artikel
Sprache:eng
Schlagworte:
Combinatorial Chemistry Techniques - instrumentation
Combinatorial Chemistry Techniques - methods
Microwaves
Molecular Structure
Peptoids - chemical synthesis
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Zusammenfassung:A range of peptoids can be prepared efficiently using microwave-assisted solid-phase chemistry in a commercial reactor. This method is most effective for the installation of electronically deactivated benzylic amines. The systematic incorporation of these amines into peptoids can deliver oligomers capable of displaying unique and stable structural motifsmicrowave-assisted solid-phase synthesis will enable their future study and application.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0502984