Effects of methylphenidate on cognitive function and gait in patients with Parkinson's disease: a pilot study

Twenty-one patients with Parkinson's disease were studied before and 2 h after the administration of a single dose of 20 mg of methylphenidate. In response to methylphenidate, attention significantly improved, whereas memory and visual-spatial performance were unchanged. Gait speed, stride time...

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Veröffentlicht in:	Clinical neuropharmacology 2006-01, Vol.29 (1), p.15-17
Hauptverfasser:	Auriel, Eitan, Hausdorff, Jeffrey M, Herman, Talia, Simon, Ely S, Giladi, Nir
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Attention - drug effects Central Nervous System Stimulants - administration & dosage Cognition - drug effects Drug Administration Schedule Female Gait - drug effects Humans Male Methylphenidate - administration & dosage Motor Activity - drug effects Neuropsychological Tests - statistics & numerical data Parkinson Disease - drug therapy Parkinson Disease - physiopathology Pilot Projects Problem Solving - drug effects Psychomotor Performance - drug effects
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Zusammenfassung:	Twenty-one patients with Parkinson's disease were studied before and 2 h after the administration of a single dose of 20 mg of methylphenidate. In response to methylphenidate, attention significantly improved, whereas memory and visual-spatial performance were unchanged. Gait speed, stride time variability, and Timed Up and Go times (demonstrated measures of fall risk) significantly improved. These findings suggest a new potential pharmacologic means of enhancing mobility and decreasing fall risk in Parkinson's disease.
ISSN:	0362-5664
DOI:	10.1097/00002826-200601000-00005