Long-term survival and functional results after aortic valve replacement in asymptomatic patients with chronic severe aortic regurgitation and left ventricular dysfunction

We examined the influence of medical treatment on the results of surgery in terms of long-term survival and functional results in patients with chronic, severe aortic regurgitation (AR). Asymptomatic patients with AR and a reduced left ventricular ejection fraction (LVEF) are at high risk because of...

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Veröffentlicht in:	Journal of the American College of Cardiology 2005-04, Vol.45 (7), p.1025-1030
Hauptverfasser:	Scognamiglio, Roldano, Negut, Christian, Palisi, Monica, Fasoli, Giuseppe, Dalla-Volta, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aortic Valve Insufficiency - diagnostic imaging Aortic Valve Insufficiency - mortality Aortic Valve Insufficiency - pathology Aortic Valve Insufficiency - physiopathology Aortic Valve Insufficiency - therapy Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular disease Chronic Disease Combined Modality Therapy Drug Administration Schedule Echocardiography Endocardial and cardiac valvular diseases Female Heart Heart attacks Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Valve Prosthesis Implantation Humans Hypertension Italy - epidemiology Longitudinal Studies Male Medical sciences Middle Aged Morbidity Mortality Nifedipine - administration & dosage Prospective Studies Randomized Controlled Trials as Topic Severity of Illness Index Studies Surgery Survival Analysis Treatment Outcome Vasodilator Agents - administration & dosage Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - mortality Ventricular Dysfunction, Left - pathology Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - therapy
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Zusammenfassung:	We examined the influence of medical treatment on the results of surgery in terms of long-term survival and functional results in patients with chronic, severe aortic regurgitation (AR). Asymptomatic patients with AR and a reduced left ventricular ejection fraction (LVEF) are at high risk because of a higher-than-expected long-term mortality. The influence of preoperative medical therapy on the outcome after aortic valve replacement (AVR) is not well known. Surgery was indicated for the appearance of a reduced LVEF (
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2004.06.081