Delayed or delayed sequential bone marrow transplantation : relevance for acute graft-versus-host disease prevention after major H2 incompatible transplantation

During this study, BalB/C mice were used as recipients and C57 bl/6 mice as donors. Recipients were given 800 cGys of total body irradiation (TBI) on day 0. Transplantation was carried out as follows: group (1): TBI on day 0; group (2): TBI on day 0 and transplantation on day +1; group (3): TBI on day 0 and transplantation on day 4; group (4): TBI on day 0 and transplantation started from day 4 through day 8. Mice that received TBI only died by day 11. All group 2 mice developed aGVHD and died by day +15. In total, 70% of group 3 were still surviving by day 60 (P