Effect of Treatment, during Primary Infection, on Establishment and Clearance of Cellular Reservoirs of HIV-1

Patients in whom virologic suppression is achieved with highly active antiretroviral therapy (HAART) retain long-lived cellular reservoirs of human immunodeficiency virus type 1 (HIV-1); this retention is an obstacle to sustained control of infection. To assess the impact that initiating treatment d...

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Veröffentlicht in:	The Journal of infectious diseases 2005-05, Vol.191 (9), p.1410-1418
Hauptverfasser:	Strain, Matthew C., Little, Susan J., Daar, Eric S., Havlir, Diane V., Günthard, Huldrych F., Lam, Ruby Y., Daly, Otto A., Nguyen, Juin, Ignacio, Caroline C., Spina, Celsa A., Richman, Douglas D., Wong, Joseph K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - virology Antiretroviral Therapy, Highly Active Antiretrovirals Disease reservoirs DNA DNA, Viral - blood DNA, Viral - genetics Half lives Highly active antiretroviral therapy HIV HIV 1 HIV Seropositivity HIV-1 - drug effects HIV-1 - isolation & purification HIV/AIDS Human immunodeficiency virus 1 Humans Infections Kinetics T lymphocytes Time Factors Viruses
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Zusammenfassung:	Patients in whom virologic suppression is achieved with highly active antiretroviral therapy (HAART) retain long-lived cellular reservoirs of human immunodeficiency virus type 1 (HIV-1); this retention is an obstacle to sustained control of infection. To assess the impact that initiating treatment during primary HIV-1 infection has on this cell population, we analyzed the decay kinetics of HIV-1 DNA and of infectivity associated with cells activated ex vivo in 27 patients who initiated therapy before or
ISSN:	0022-1899 1537-6613
DOI:	10.1086/428777