Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02

In vitro antifungal activities of several semi-synthesized analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02 against Saccharomyces cerevisiae IFO 0203 were evaluated by the conventional paper disk method. Several derivatives exhibited growth inhibitory activity...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-04, Vol.15 (8), p.2011-2014
Hauptverfasser:	Usuki, Yoshinosuke, Mitomo, Koichi, Adachi, Noriko, Ping, Xu, Fujita, Ken-Ichi, Sakanaka, Osamu, Iinuma, Katsuharu, Iio, Hideo, Taniguchi, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal activity Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Biological and medical sciences Drug Evaluation, Preclinical - methods General aspects Lactones - chemical synthesis Lactones - pharmacology Medical sciences Nine-membered dilactone Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - pharmacology Respiratory inhibition Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - growth & development Streptomyces - chemistry Structure–activity relationship UK-2A
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Zusammenfassung:	In vitro antifungal activities of several semi-synthesized analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02 against Saccharomyces cerevisiae IFO 0203 were evaluated by the conventional paper disk method. Several derivatives exhibited growth inhibitory activity similar to UK-2A. Several analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were semi-synthesized for structure–activity studies. In vitro antifungal activities of these compounds against Saccharomyces cerevisiae IFO 0203 were evaluated by the conventional paper disk method. Several derivatives exhibited growth inhibitory activity similar to UK-2A.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.02.065