Nepalensinols D—G, New Resveratrol Oligomers from Kobresia nepalensis (Cyperaceae) as Potent Inhibitors of DNA Topoisomerase II
Four new resveratrol oligomers, nepalensinols D—G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-t...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2006, Vol.54(3), pp.354-358 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | Yamada, Masashi Hayashi, Ken-ichiro Hayashi, Hiroshi Tsuji, Ryota Kakumoto, Kazuyuki Ikeda, Shogo Hoshino, Takuji Tsutsui, Ken Tsutsui, Kimiko Ito, Tetsuro Iinuma, Munekazu Nozaki, Hiroshi |
| description | Four new resveratrol oligomers, nepalensinols D—G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-tumor agents. These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5—15 μM. |
| doi_str_mv | 10.1248/cpb.54.354 |
| format | Article |
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These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5—15 μM.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.54.354</identifier><identifier>PMID: 16508191</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Cyperaceae - chemistry ; Enzyme Inhibitors - isolation & purification ; Enzyme Inhibitors - pharmacology ; Humans ; inhibitor ; Kobresia nepalensis ; Magnetic Resonance Spectroscopy ; Molecular Conformation ; nepalensinol ; Phenols - chemical synthesis ; Phenols - pharmacology ; Plant Stems - chemistry ; Resveratrol ; Spectrometry, Mass, Fast Atom Bombardment ; Spectrophotometry, Ultraviolet ; stilbene ; Stilbenes - chemical synthesis ; Stilbenes - pharmacology ; topoisomerase ; Topoisomerase II Inhibitors</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2006, Vol.54(3), pp.354-358</ispartof><rights>2006 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-bbdb39add9fb3dc6b9b7ad245e7f6fdccc9860d2e0cdcf52160d2595b7dd56613</citedby><cites>FETCH-LOGICAL-c506t-bbdb39add9fb3dc6b9b7ad245e7f6fdccc9860d2e0cdcf52160d2595b7dd56613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16508191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Masashi</creatorcontrib><creatorcontrib>Hayashi, Ken-ichiro</creatorcontrib><creatorcontrib>Hayashi, Hiroshi</creatorcontrib><creatorcontrib>Tsuji, Ryota</creatorcontrib><creatorcontrib>Kakumoto, Kazuyuki</creatorcontrib><creatorcontrib>Ikeda, Shogo</creatorcontrib><creatorcontrib>Hoshino, Takuji</creatorcontrib><creatorcontrib>Tsutsui, Ken</creatorcontrib><creatorcontrib>Tsutsui, Kimiko</creatorcontrib><creatorcontrib>Ito, Tetsuro</creatorcontrib><creatorcontrib>Iinuma, Munekazu</creatorcontrib><creatorcontrib>Nozaki, Hiroshi</creatorcontrib><title>Nepalensinols D—G, New Resveratrol Oligomers from Kobresia nepalensis (Cyperaceae) as Potent Inhibitors of DNA Topoisomerase II</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. 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These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5—15 μM.</description><subject>Cyperaceae - chemistry</subject><subject>Enzyme Inhibitors - isolation & purification</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Humans</subject><subject>inhibitor</subject><subject>Kobresia nepalensis</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Molecular Conformation</subject><subject>nepalensinol</subject><subject>Phenols - chemical synthesis</subject><subject>Phenols - pharmacology</subject><subject>Plant Stems - chemistry</subject><subject>Resveratrol</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>stilbene</subject><subject>Stilbenes - chemical synthesis</subject><subject>Stilbenes - pharmacology</subject><subject>topoisomerase</subject><subject>Topoisomerase II Inhibitors</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0d9qFDEUBvAgil2rNz6ABASp4qzJZJLMXJWyrXWxbEXqdcifM22WmcmYzCq903foE_okZtm1BW8SQn7n48CH0EtK5rSs6g92NHNezRmvHqEZZZUseFmyx2hGCGmKkgl2gJ6ltCak5ESyp-iACk5q2tAZ-r2CUXcwJD-ELuHTP7_uzt_jFfzEXyH9gKinGDp82fnr0ENMuI2hx5-DiZC8xsO_4YSPFrdj5hY0vMU64S9hgmHCy-HGGz-FPBpafLo6wVdhDD5t03QCvFw-R09a3SV4sb8P0bePZ1eLT8XF5flycXJRWE7EVBjjDGu0c01rmLPCNEZqV1YcZCtaZ61takFcCcQ62_KSbh-84UY6x4Wg7BC92eWOMXzfQJpU75OFrtMDhE1SQkpCq0Zm-Po_uA6bOOTdFK0EYbWQNcnq3U7ZGFKK0Kox-l7HW0WJ2taici2KVyrXkvGrfeTG9OAe6L6HDI53YJ0mfQ33QMfJ2w7us3ZHjnz4udFRwcD-AkkToaM</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Yamada, Masashi</creator><creator>Hayashi, Ken-ichiro</creator><creator>Hayashi, Hiroshi</creator><creator>Tsuji, Ryota</creator><creator>Kakumoto, Kazuyuki</creator><creator>Ikeda, Shogo</creator><creator>Hoshino, Takuji</creator><creator>Tsutsui, Ken</creator><creator>Tsutsui, Kimiko</creator><creator>Ito, Tetsuro</creator><creator>Iinuma, Munekazu</creator><creator>Nozaki, Hiroshi</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Nepalensinols D—G, New Resveratrol Oligomers from Kobresia nepalensis (Cyperaceae) as Potent Inhibitors of DNA Topoisomerase II</title><author>Yamada, Masashi ; Hayashi, Ken-ichiro ; Hayashi, Hiroshi ; Tsuji, Ryota ; Kakumoto, Kazuyuki ; Ikeda, Shogo ; Hoshino, Takuji ; Tsutsui, Ken ; Tsutsui, Kimiko ; Ito, Tetsuro ; Iinuma, Munekazu ; Nozaki, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-bbdb39add9fb3dc6b9b7ad245e7f6fdccc9860d2e0cdcf52160d2595b7dd56613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Cyperaceae - chemistry</topic><topic>Enzyme Inhibitors - isolation & purification</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Humans</topic><topic>inhibitor</topic><topic>Kobresia nepalensis</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Molecular Conformation</topic><topic>nepalensinol</topic><topic>Phenols - chemical synthesis</topic><topic>Phenols - pharmacology</topic><topic>Plant Stems - chemistry</topic><topic>Resveratrol</topic><topic>Spectrometry, Mass, Fast Atom Bombardment</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>stilbene</topic><topic>Stilbenes - chemical synthesis</topic><topic>Stilbenes - pharmacology</topic><topic>topoisomerase</topic><topic>Topoisomerase II Inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Masashi</creatorcontrib><creatorcontrib>Hayashi, Ken-ichiro</creatorcontrib><creatorcontrib>Hayashi, Hiroshi</creatorcontrib><creatorcontrib>Tsuji, Ryota</creatorcontrib><creatorcontrib>Kakumoto, Kazuyuki</creatorcontrib><creatorcontrib>Ikeda, Shogo</creatorcontrib><creatorcontrib>Hoshino, Takuji</creatorcontrib><creatorcontrib>Tsutsui, Ken</creatorcontrib><creatorcontrib>Tsutsui, Kimiko</creatorcontrib><creatorcontrib>Ito, Tetsuro</creatorcontrib><creatorcontrib>Iinuma, Munekazu</creatorcontrib><creatorcontrib>Nozaki, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Masashi</au><au>Hayashi, Ken-ichiro</au><au>Hayashi, Hiroshi</au><au>Tsuji, Ryota</au><au>Kakumoto, Kazuyuki</au><au>Ikeda, Shogo</au><au>Hoshino, Takuji</au><au>Tsutsui, Ken</au><au>Tsutsui, Kimiko</au><au>Ito, Tetsuro</au><au>Iinuma, Munekazu</au><au>Nozaki, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nepalensinols D—G, New Resveratrol Oligomers from Kobresia nepalensis (Cyperaceae) as Potent Inhibitors of DNA Topoisomerase II</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>54</volume><issue>3</issue><spage>354</spage><epage>358</epage><pages>354-358</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Four new resveratrol oligomers, nepalensinols D—G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-tumor agents. These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5—15 μM.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>16508191</pmid><doi>10.1248/cpb.54.354</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Cyperaceae - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Humans inhibitor Kobresia nepalensis Magnetic Resonance Spectroscopy Molecular Conformation nepalensinol Phenols - chemical synthesis Phenols - pharmacology Plant Stems - chemistry Resveratrol Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Ultraviolet stilbene Stilbenes - chemical synthesis Stilbenes - pharmacology topoisomerase Topoisomerase II Inhibitors |
| title | Nepalensinols D—G, New Resveratrol Oligomers from Kobresia nepalensis (Cyperaceae) as Potent Inhibitors of DNA Topoisomerase II |
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