Nepalensinols D—G, New Resveratrol Oligomers from Kobresia nepalensis (Cyperaceae) as Potent Inhibitors of DNA Topoisomerase II

Four new resveratrol oligomers, nepalensinols D—G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-t...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2006, Vol.54(3), pp.354-358
Hauptverfasser:	Yamada, Masashi, Hayashi, Ken-ichiro, Hayashi, Hiroshi, Tsuji, Ryota, Kakumoto, Kazuyuki, Ikeda, Shogo, Hoshino, Takuji, Tsutsui, Ken, Tsutsui, Kimiko, Ito, Tetsuro, Iinuma, Munekazu, Nozaki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyperaceae - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Humans inhibitor Kobresia nepalensis Magnetic Resonance Spectroscopy Molecular Conformation nepalensinol Phenols - chemical synthesis Phenols - pharmacology Plant Stems - chemistry Resveratrol Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Ultraviolet stilbene Stilbenes - chemical synthesis Stilbenes - pharmacology topoisomerase Topoisomerase II Inhibitors
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Zusammenfassung:	Four new resveratrol oligomers, nepalensinols D—G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-tumor agents. These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5—15 μM.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.54.354