Reestablishment of a transgenic rabbit line by artificial insemination using cryopreserved semen

Reestablishment of a transgenic rabbit line by artificial insemination using cryopreserved semen

The production of recombinant proteins in the milk of transgenic animals is an alternative to traditional cell culture methodology. Transgenic rabbits can serve in the small-scale production of recombinant proteins, underscoring the need to maintain valuable transgenic lines. In this study, the auth...

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Veröffentlicht in:Lab animal 2005-04, Vol.34 (4), p.61-63
Hauptverfasser: Blash, Stephen, Chen, Lihow, Harvey, Merry, Gavin, William G.
Format: Artikel
Sprache:eng
Schlagworte:
Animal Husbandry - methods
Animal Models
Animals
Animals, Genetically Modified - genetics
Biomedical and Life Sciences
Breeding - methods
Cryopreservation
Female
Insemination, Artificial - methods
Life Sciences
Litter Size
Male
Rabbits - genetics
research-note
Semen - cytology
Semen - physiology
Semen Preservation - methods
Spermatozoa - cytology
Spermatozoa - physiology
Veterinary Medicine - methods
Veterinary Medicine/Veterinary Science
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Beschreibung
Zusammenfassung:The production of recombinant proteins in the milk of transgenic animals is an alternative to traditional cell culture methodology. Transgenic rabbits can serve in the small-scale production of recombinant proteins, underscoring the need to maintain valuable transgenic lines. In this study, the authors used cryopreserved transgenic rabbit semen to artificially inseminate does, demonstrating the utility of this method for the reestablishment of a transgenic rabbit herd.
ISSN:0093-7355
1548-4475
DOI:10.1038/laban0405-61