Short-Term Regulation of Tumor Necrosis Factor-α-Induced Lipolysis in 3T3-L1 Adipocytes Is Mediated through the Inducible Nitric Oxide Synthase/Nitric Oxide-Dependent Pathway

TNF-α has several effects on adipocytes that may be related to the development of type 2 diabetes in obese subjects. Many studies demonstrated that long-term treatment with TNF-α increases lipolysis in adipocytes. However, the short-term (

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Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2009-11, Vol.150 (11), p.4892-4900
Hauptverfasser:	Lien, Chih-Chan, Au, Lo-Chun, Tsai, Ying-Lan, Ho, Low-Tone, Juan, Chi-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Adipocytes Adipocytes - drug effects Adipocytes - enzymology Adipocytes - metabolism Animals Cyclic GMP Diabetes mellitus (non-insulin dependent) Gene expression Gene Expression - drug effects Guanylate cyclase Immunoprecipitation Inhibitors Lipolysis Lipolysis - drug effects Mice NIH 3T3 Cells Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Phosphorylation Reagents Regulatory mechanisms (biology) Signal Transduction - drug effects Transfection Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumor necrosis factor-α Western blotting
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Beschreibung
Zusammenfassung:	TNF-α has several effects on adipocytes that may be related to the development of type 2 diabetes in obese subjects. Many studies demonstrated that long-term treatment with TNF-α increases lipolysis in adipocytes. However, the short-term (
ISSN:	0013-7227 1945-7170
DOI:	10.1210/en.2009-0403