Subcutaneous anti-D treatment of idiopathic thrombocytopenic purpura in children
We investigated the effect of subcutaneous anti‐D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 109 to 31 × 109/L on day 3 (P ...
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Veröffentlicht in: | Pediatric blood & cancer 2009-12, Vol.53 (7), p.1315-1317 |
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description | We investigated the effect of subcutaneous anti‐D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 109 to 31 × 109/L on day 3 (P |
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Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 109 to 31 × 109/L on day 3 (P < 0.01). The median decline in hemoglobin was 1.3 g/dl. Two children experienced minor fever and chills within 24 hr of treatment. Pain at the injection site was common but self‐limiting with no effect on activity level. These results suggest subcutaneous anti‐D IgG 50 µg/kg as an effective and well‐tolerated treatment option in childhood ITP. Pediatr Blood Cancer 2009; 53:1315–1317. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.22248</identifier><identifier>PMID: 19722275</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; anti-D ; bleeding score ; Child ; Child, Preschool ; childhood ; Chills - etiology ; Female ; Fever - etiology ; Hemoglobins - analysis ; Hemorrhage - etiology ; Humans ; Immunotherapy ; Infant ; Injections, Subcutaneous ; Isoantibodies - administration & dosage ; Isoantibodies - adverse effects ; Isoantibodies - therapeutic use ; ITP ; Male ; Pain - etiology ; Platelet Count ; Prospective Studies ; Purpura, Thrombocytopenic, Idiopathic - blood ; Purpura, Thrombocytopenic, Idiopathic - complications ; Purpura, Thrombocytopenic, Idiopathic - therapy ; Rho(D) Immune Globulin ; subcutaneous</subject><ispartof>Pediatric blood & cancer, 2009-12, Vol.53 (7), p.1315-1317</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><rights>(c) 2009 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4278-8259781b028c0cfe80eba7f3dad85106d13a221d73fbf9c6e44a4c40ad5a883a3</citedby><cites>FETCH-LOGICAL-c4278-8259781b028c0cfe80eba7f3dad85106d13a221d73fbf9c6e44a4c40ad5a883a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.22248$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.22248$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19722275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kjaersgaard, Mimi</creatorcontrib><creatorcontrib>Edslev, Pernille Wendtland</creatorcontrib><creatorcontrib>Hasle, Henrik</creatorcontrib><title>Subcutaneous anti-D treatment of idiopathic thrombocytopenic purpura in children</title><title>Pediatric blood & cancer</title><addtitle>Pediatr. Blood Cancer</addtitle><description>We investigated the effect of subcutaneous anti‐D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 109 to 31 × 109/L on day 3 (P < 0.01). The median decline in hemoglobin was 1.3 g/dl. Two children experienced minor fever and chills within 24 hr of treatment. Pain at the injection site was common but self‐limiting with no effect on activity level. These results suggest subcutaneous anti‐D IgG 50 µg/kg as an effective and well‐tolerated treatment option in childhood ITP. Pediatr Blood Cancer 2009; 53:1315–1317. © 2009 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>anti-D</subject><subject>bleeding score</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>childhood</subject><subject>Chills - etiology</subject><subject>Female</subject><subject>Fever - etiology</subject><subject>Hemoglobins - analysis</subject><subject>Hemorrhage - etiology</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Infant</subject><subject>Injections, Subcutaneous</subject><subject>Isoantibodies - administration & dosage</subject><subject>Isoantibodies - adverse effects</subject><subject>Isoantibodies - therapeutic use</subject><subject>ITP</subject><subject>Male</subject><subject>Pain - etiology</subject><subject>Platelet Count</subject><subject>Prospective Studies</subject><subject>Purpura, Thrombocytopenic, Idiopathic - blood</subject><subject>Purpura, Thrombocytopenic, Idiopathic - complications</subject><subject>Purpura, Thrombocytopenic, Idiopathic - therapy</subject><subject>Rho(D) Immune Globulin</subject><subject>subcutaneous</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9LAzEQxYMoVqsHv4DsSfCwbZLdbLJHW7UKopVWegzZbJZG959JFu23N7q1noSBGYbfe8w8AM4QHCEI8bjN5AhjHLM9cIRITEICEd3fzTAdgGNrXz2aQMIOwQCl1POUHIH5ostk50Stms4GonY6vA6cUcJVqnZBUwQ6100r3FrLwK1NU2WN3LimVbVftJ3xJQJdB3Kty9yo-gQcFKK06nTbh-Dl9mY5vQsfnmb306uHUMaYspBhklKGMoiZhLJQDKpM0CLKRc4IgkmOIoExymlUZEUqExXHIpYxFDkRjEUiGoKL3rc1zXunrOOVtlKVZf8KT2iSRjDGHrzsQWkaa40qeGt0JcyGI8i_4-M-Pv4Tn2fPt6ZdVqn8j9zm5YFxD3zoUm3-d-LzyfTXMuwV2jr1uVMI8-ZPjCjhq8cZn0wXy-cVmvNl9AUct4nL</recordid><startdate>20091215</startdate><enddate>20091215</enddate><creator>Kjaersgaard, Mimi</creator><creator>Edslev, Pernille Wendtland</creator><creator>Hasle, Henrik</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091215</creationdate><title>Subcutaneous anti-D treatment of idiopathic thrombocytopenic purpura in children</title><author>Kjaersgaard, Mimi ; Edslev, Pernille Wendtland ; Hasle, Henrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4278-8259781b028c0cfe80eba7f3dad85106d13a221d73fbf9c6e44a4c40ad5a883a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>anti-D</topic><topic>bleeding score</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>childhood</topic><topic>Chills - etiology</topic><topic>Female</topic><topic>Fever - etiology</topic><topic>Hemoglobins - analysis</topic><topic>Hemorrhage - etiology</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Infant</topic><topic>Injections, Subcutaneous</topic><topic>Isoantibodies - administration & dosage</topic><topic>Isoantibodies - adverse effects</topic><topic>Isoantibodies - therapeutic use</topic><topic>ITP</topic><topic>Male</topic><topic>Pain - etiology</topic><topic>Platelet Count</topic><topic>Prospective Studies</topic><topic>Purpura, Thrombocytopenic, Idiopathic - blood</topic><topic>Purpura, Thrombocytopenic, Idiopathic - complications</topic><topic>Purpura, Thrombocytopenic, Idiopathic - therapy</topic><topic>Rho(D) Immune Globulin</topic><topic>subcutaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kjaersgaard, Mimi</creatorcontrib><creatorcontrib>Edslev, Pernille Wendtland</creatorcontrib><creatorcontrib>Hasle, Henrik</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kjaersgaard, Mimi</au><au>Edslev, Pernille Wendtland</au><au>Hasle, Henrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subcutaneous anti-D treatment of idiopathic thrombocytopenic purpura in children</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr. Blood Cancer</addtitle><date>2009-12-15</date><risdate>2009</risdate><volume>53</volume><issue>7</issue><spage>1315</spage><epage>1317</epage><pages>1315-1317</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>We investigated the effect of subcutaneous anti‐D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 109 to 31 × 109/L on day 3 (P < 0.01). The median decline in hemoglobin was 1.3 g/dl. Two children experienced minor fever and chills within 24 hr of treatment. Pain at the injection site was common but self‐limiting with no effect on activity level. These results suggest subcutaneous anti‐D IgG 50 µg/kg as an effective and well‐tolerated treatment option in childhood ITP. 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subjects | Adolescent anti-D bleeding score Child Child, Preschool childhood Chills - etiology Female Fever - etiology Hemoglobins - analysis Hemorrhage - etiology Humans Immunotherapy Infant Injections, Subcutaneous Isoantibodies - administration & dosage Isoantibodies - adverse effects Isoantibodies - therapeutic use ITP Male Pain - etiology Platelet Count Prospective Studies Purpura, Thrombocytopenic, Idiopathic - blood Purpura, Thrombocytopenic, Idiopathic - complications Purpura, Thrombocytopenic, Idiopathic - therapy Rho(D) Immune Globulin subcutaneous |
title | Subcutaneous anti-D treatment of idiopathic thrombocytopenic purpura in children |
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