Subcutaneous anti-D treatment of idiopathic thrombocytopenic purpura in children

We investigated the effect of subcutaneous anti‐D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 109 to 31 × 109/L on day 3 (P ...

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Veröffentlicht in:Pediatric blood & cancer 2009-12, Vol.53 (7), p.1315-1317
Hauptverfasser: Kjaersgaard, Mimi, Edslev, Pernille Wendtland, Hasle, Henrik
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creator Kjaersgaard, Mimi
Edslev, Pernille Wendtland
Hasle, Henrik
description We investigated the effect of subcutaneous anti‐D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 109 to 31 × 109/L on day 3 (P 
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Blood Cancer</addtitle><description>We investigated the effect of subcutaneous anti‐D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 109 to 31 × 109/L on day 3 (P &lt; 0.01). The median decline in hemoglobin was 1.3 g/dl. Two children experienced minor fever and chills within 24 hr of treatment. Pain at the injection site was common but self‐limiting with no effect on activity level. These results suggest subcutaneous anti‐D IgG 50 µg/kg as an effective and well‐tolerated treatment option in childhood ITP. 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Blood Cancer</addtitle><date>2009-12-15</date><risdate>2009</risdate><volume>53</volume><issue>7</issue><spage>1315</spage><epage>1317</epage><pages>1315-1317</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>We investigated the effect of subcutaneous anti‐D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 109 to 31 × 109/L on day 3 (P &lt; 0.01). The median decline in hemoglobin was 1.3 g/dl. Two children experienced minor fever and chills within 24 hr of treatment. Pain at the injection site was common but self‐limiting with no effect on activity level. These results suggest subcutaneous anti‐D IgG 50 µg/kg as an effective and well‐tolerated treatment option in childhood ITP. Pediatr Blood Cancer 2009; 53:1315–1317. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19722275</pmid><doi>10.1002/pbc.22248</doi><tpages>3</tpages></addata></record>
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subjects Adolescent
anti-D
bleeding score
Child
Child, Preschool
childhood
Chills - etiology
Female
Fever - etiology
Hemoglobins - analysis
Hemorrhage - etiology
Humans
Immunotherapy
Infant
Injections, Subcutaneous
Isoantibodies - administration & dosage
Isoantibodies - adverse effects
Isoantibodies - therapeutic use
ITP
Male
Pain - etiology
Platelet Count
Prospective Studies
Purpura, Thrombocytopenic, Idiopathic - blood
Purpura, Thrombocytopenic, Idiopathic - complications
Purpura, Thrombocytopenic, Idiopathic - therapy
Rho(D) Immune Globulin
subcutaneous
title Subcutaneous anti-D treatment of idiopathic thrombocytopenic purpura in children
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