Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities
The semisynthesis and SAR study of C-ring modified cytotoxic triptolide analogues were reported. Several C-ring modified analogues of a potent antileukemic diterpene, triptolide ( 1), were synthesized and their structure–activity relationships were studied.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2006-04, Vol.16 (7), p.1947-1949 |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
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| container_end_page | 1949 |
|---|---|
| container_issue | 7 |
| container_start_page | 1947 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 16 |
| creator | Aoyagi, Yutaka Hitotsuyanagi, Yukio Hasuda, Tomoyo Fukaya, Haruhiko Takeya, Koichi Aiyama, Ritsuo Matsuzaki, Takeshi Hashimoto, Shusuke |
| description | The semisynthesis and SAR study of C-ring modified cytotoxic triptolide analogues were reported.
Several C-ring modified analogues of a potent antileukemic diterpene, triptolide (
1), were synthesized and their structure–activity relationships were studied. |
| doi_str_mv | 10.1016/j.bmcl.2005.12.098 |
| format | Article |
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Several C-ring modified analogues of a potent antileukemic diterpene, triptolide (
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1947-1949 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antineoplastic agents Antitumor Biological and medical sciences C-ring Cell Line, Tumor Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology Drug Screening Assays, Antitumor Epoxy Compounds General aspects Humans Medical sciences Miscellaneous Models, Molecular Pharmacology. Drug treatments Phenanthrenes - chemical synthesis Phenanthrenes - chemistry Phenanthrenes - pharmacology Semisynthesis Structure-Activity Relationship Structure–activity relationships Triptolide analogues |
| title | Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities |
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