Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities

The semisynthesis and SAR study of C-ring modified cytotoxic triptolide analogues were reported. Several C-ring modified analogues of a potent antileukemic diterpene, triptolide ( 1), were synthesized and their structure–activity relationships were studied.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-04, Vol.16 (7), p.1947-1949
Hauptverfasser:	Aoyagi, Yutaka, Hitotsuyanagi, Yukio, Hasuda, Tomoyo, Fukaya, Haruhiko, Takeya, Koichi, Aiyama, Ritsuo, Matsuzaki, Takeshi, Hashimoto, Shusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antitumor Biological and medical sciences C-ring Cell Line, Tumor Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology Drug Screening Assays, Antitumor Epoxy Compounds General aspects Humans Medical sciences Miscellaneous Models, Molecular Pharmacology. Drug treatments Phenanthrenes - chemical synthesis Phenanthrenes - chemistry Phenanthrenes - pharmacology Semisynthesis Structure-Activity Relationship Structure–activity relationships Triptolide analogues
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The semisynthesis and SAR study of C-ring modified cytotoxic triptolide analogues were reported. Several C-ring modified analogues of a potent antileukemic diterpene, triptolide ( 1), were synthesized and their structure–activity relationships were studied.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.12.098