Synthesis and antifungal activity of 6-hydroxycinnolines

6-Hydroxycinnolines and cyclohexa-2,5-diene-1,4-dione derivatives were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. Among them, 2-amino-7,8-dimethyl-6-hydroxycinnolines exhibited potent antifungal activity. 6-Hydroxycinnolines 2 and cyclohexa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-04, Vol.16 (7), p.1850-1853
Hauptverfasser:	Ryu, Chung-Kyu, Lee, Jung Yoon
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxycinnoline Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antimicrobial compounds Aspergillus Aspergillus - drug effects Biological and medical sciences Candida Candida - drug effects Fungi General aspects Heterocyclic Compounds, 2-Ring - chemical synthesis Heterocyclic Compounds, 2-Ring - chemistry Heterocyclic Compounds, 2-Ring - pharmacology Medical sciences Molecular Structure Pharmacology. Drug treatments Substitution effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	6-Hydroxycinnolines and cyclohexa-2,5-diene-1,4-dione derivatives were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. Among them, 2-amino-7,8-dimethyl-6-hydroxycinnolines exhibited potent antifungal activity. 6-Hydroxycinnolines 2 and cyclohexa-2,5-diene-1,4-dione derivatives 6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 6-Hydroxycinnolines 2 showed, in general, more potent antifungal activity against Candida species than the other cyclohexa-2,5-diene-1,4-diones. The results suggest that 6-hydroxycinnolines would be potent antifungal agents.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.01.005