Age-related change in the damage morphology of human cortical bone and its role in bone fragility
Application of cyclic loading results in the formation of distinct strain-dependent microdamage morphologies. It is still unknown; however, how the morphology of microdamage affects age-related increase in bone fragility. In this study, four-point bending fatigue tests were conducted on aging human...
Gespeichert in:
| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2006-03, Vol.38 (3), p.427-431 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 431 |
|---|---|
| container_issue | 3 |
| container_start_page | 427 |
| container_title | Bone (New York, N.Y.) |
| container_volume | 38 |
| creator | Diab, Tamim Condon, Keith W. Burr, David B. Vashishth, Deepak |
| description | Application of cyclic loading results in the formation of distinct strain-dependent microdamage morphologies. It is still unknown; however, how the morphology of microdamage affects age-related increase in bone fragility. In this study, four-point bending fatigue tests were conducted on aging human bone (age 26 to 89) in conjunction with histological evaluation of the resultant tensile (diffuse damage) and compressive (linear microcracks) damage to identify the damage morphologies associated with an increase in age-related bone fragility. The results demonstrate that young donors (38 ± 9 years) had a longer fatigue life (
P |
| doi_str_mv | 10.1016/j.bone.2005.09.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67686135</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S8756328205003789</els_id><sourcerecordid>67686135</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-f43490d4fac38ca95effc8b06f482e1b9c21c33aeac06b5e874c39e10b20bb8e3</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhoMo7rj6BzxILnrrtpJ05wO8LItfsOBFzyGdrsxk6O6MSY8w_97MzsDe9FRU8bxF1fsS8pZBy4DJj_t2SAu2HKBvwbQA_BnZMK1Ew5UUz8lGq142gmt-Q16VsgcAYRR7SW6Y5BKY6TfE3W2xyTi5FUfqd27ZIo0LXXdIRze72s0pH3ZpStsTTYHujrNbqE95jd5N9HwAdctI41poTtOj-HEYstvGKa6n1-RFcFPBN9d6S359-fzz_lvz8OPr9_u7h8Z3mq1N6ERnYOyC80J7Z3oMwesBZOg0RzYYz5kXwqHzIIceteq8MMhg4DAMGsUt-XDZe8jp9xHLaudYPE6TWzAdi5VKaslE_1-QKQaa96yC_AL6nErJGOwhx9nlk2VgzwnYvT3_as8JWDC2JlBF767bj8OM45PkankF3l8BV6qF1afFx_LEqd4wxXXlPl04rKb9iZht8REXj2PM6Fc7pvivO_4CN_ikxw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17108251</pqid></control><display><type>article</type><title>Age-related change in the damage morphology of human cortical bone and its role in bone fragility</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Diab, Tamim ; Condon, Keith W. ; Burr, David B. ; Vashishth, Deepak</creator><creatorcontrib>Diab, Tamim ; Condon, Keith W. ; Burr, David B. ; Vashishth, Deepak</creatorcontrib><description>Application of cyclic loading results in the formation of distinct strain-dependent microdamage morphologies. It is still unknown; however, how the morphology of microdamage affects age-related increase in bone fragility. In this study, four-point bending fatigue tests were conducted on aging human bone (age 26 to 89) in conjunction with histological evaluation of the resultant tensile (diffuse damage) and compressive (linear microcracks) damage to identify the damage morphologies associated with an increase in age-related bone fragility. The results demonstrate that young donors (38 ± 9 years) had a longer fatigue life (
P < 0.05) and formed more diffuse damage than the older donors (82 ± 5 years) (
P < 0.05). In contrast, old donors had a shorter fatigue life and formed more linear microcracks than the younger donors (
P < 0.05). Linear microcracks were longer in older than in younger donors (
P < 0.05) and were associated with weak lamellar interfaces. Areas of diffuse damage were, however, larger in younger than in older donors (
P < 0.05), and these showed no relationship with the lamellar arrangement of bone. These findings show, for the first time, that the propensity of bone to form a particular damage morphology is subject to change with age and that the propensity of young donors to form diffuse damage over interlamellae linear microcracks plays a critical role in the ability of bone to dissipate energy and resist a catastrophic fracture. Age-related changes in damage morphology may therefore be an important contributor to the increased bone fragility in the elderly.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2005.09.002</identifier><identifier>PMID: 16260195</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Aging - physiology ; Bending fatigue ; Biological and medical sciences ; Bone and Bones - injuries ; Bone and Bones - pathology ; Bone and Bones - physiopathology ; Bone Density ; Bone Development ; Bone Remodeling ; Compressive Strength ; Cortical bone ; Diffuse damage ; Fractures, Stress ; Fundamental and applied biological sciences. Psychology ; Humans ; Microcracks ; Microscopy, Confocal ; Middle Aged ; Stress, Mechanical ; Tensile Strength ; Tibia - injuries ; Tibia - pathology ; Tibia - physiopathology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.427-431</ispartof><rights>2005 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-f43490d4fac38ca95effc8b06f482e1b9c21c33aeac06b5e874c39e10b20bb8e3</citedby><cites>FETCH-LOGICAL-c481t-f43490d4fac38ca95effc8b06f482e1b9c21c33aeac06b5e874c39e10b20bb8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S8756328205003789$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17591728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16260195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diab, Tamim</creatorcontrib><creatorcontrib>Condon, Keith W.</creatorcontrib><creatorcontrib>Burr, David B.</creatorcontrib><creatorcontrib>Vashishth, Deepak</creatorcontrib><title>Age-related change in the damage morphology of human cortical bone and its role in bone fragility</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Application of cyclic loading results in the formation of distinct strain-dependent microdamage morphologies. It is still unknown; however, how the morphology of microdamage affects age-related increase in bone fragility. In this study, four-point bending fatigue tests were conducted on aging human bone (age 26 to 89) in conjunction with histological evaluation of the resultant tensile (diffuse damage) and compressive (linear microcracks) damage to identify the damage morphologies associated with an increase in age-related bone fragility. The results demonstrate that young donors (38 ± 9 years) had a longer fatigue life (
P < 0.05) and formed more diffuse damage than the older donors (82 ± 5 years) (
P < 0.05). In contrast, old donors had a shorter fatigue life and formed more linear microcracks than the younger donors (
P < 0.05). Linear microcracks were longer in older than in younger donors (
P < 0.05) and were associated with weak lamellar interfaces. Areas of diffuse damage were, however, larger in younger than in older donors (
P < 0.05), and these showed no relationship with the lamellar arrangement of bone. These findings show, for the first time, that the propensity of bone to form a particular damage morphology is subject to change with age and that the propensity of young donors to form diffuse damage over interlamellae linear microcracks plays a critical role in the ability of bone to dissipate energy and resist a catastrophic fracture. Age-related changes in damage morphology may therefore be an important contributor to the increased bone fragility in the elderly.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Bending fatigue</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - injuries</subject><subject>Bone and Bones - pathology</subject><subject>Bone and Bones - physiopathology</subject><subject>Bone Density</subject><subject>Bone Development</subject><subject>Bone Remodeling</subject><subject>Compressive Strength</subject><subject>Cortical bone</subject><subject>Diffuse damage</subject><subject>Fractures, Stress</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Microcracks</subject><subject>Microscopy, Confocal</subject><subject>Middle Aged</subject><subject>Stress, Mechanical</subject><subject>Tensile Strength</subject><subject>Tibia - injuries</subject><subject>Tibia - pathology</subject><subject>Tibia - physiopathology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6BzxILnrrtpJ05wO8LItfsOBFzyGdrsxk6O6MSY8w_97MzsDe9FRU8bxF1fsS8pZBy4DJj_t2SAu2HKBvwbQA_BnZMK1Ew5UUz8lGq142gmt-Q16VsgcAYRR7SW6Y5BKY6TfE3W2xyTi5FUfqd27ZIo0LXXdIRze72s0pH3ZpStsTTYHujrNbqE95jd5N9HwAdctI41poTtOj-HEYstvGKa6n1-RFcFPBN9d6S359-fzz_lvz8OPr9_u7h8Z3mq1N6ERnYOyC80J7Z3oMwesBZOg0RzYYz5kXwqHzIIceteq8MMhg4DAMGsUt-XDZe8jp9xHLaudYPE6TWzAdi5VKaslE_1-QKQaa96yC_AL6nErJGOwhx9nlk2VgzwnYvT3_as8JWDC2JlBF767bj8OM45PkankF3l8BV6qF1afFx_LEqd4wxXXlPl04rKb9iZht8REXj2PM6Fc7pvivO_4CN_ikxw</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Diab, Tamim</creator><creator>Condon, Keith W.</creator><creator>Burr, David B.</creator><creator>Vashishth, Deepak</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Age-related change in the damage morphology of human cortical bone and its role in bone fragility</title><author>Diab, Tamim ; Condon, Keith W. ; Burr, David B. ; Vashishth, Deepak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-f43490d4fac38ca95effc8b06f482e1b9c21c33aeac06b5e874c39e10b20bb8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Bending fatigue</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - injuries</topic><topic>Bone and Bones - pathology</topic><topic>Bone and Bones - physiopathology</topic><topic>Bone Density</topic><topic>Bone Development</topic><topic>Bone Remodeling</topic><topic>Compressive Strength</topic><topic>Cortical bone</topic><topic>Diffuse damage</topic><topic>Fractures, Stress</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Microcracks</topic><topic>Microscopy, Confocal</topic><topic>Middle Aged</topic><topic>Stress, Mechanical</topic><topic>Tensile Strength</topic><topic>Tibia - injuries</topic><topic>Tibia - pathology</topic><topic>Tibia - physiopathology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diab, Tamim</creatorcontrib><creatorcontrib>Condon, Keith W.</creatorcontrib><creatorcontrib>Burr, David B.</creatorcontrib><creatorcontrib>Vashishth, Deepak</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diab, Tamim</au><au>Condon, Keith W.</au><au>Burr, David B.</au><au>Vashishth, Deepak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related change in the damage morphology of human cortical bone and its role in bone fragility</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>38</volume><issue>3</issue><spage>427</spage><epage>431</epage><pages>427-431</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>Application of cyclic loading results in the formation of distinct strain-dependent microdamage morphologies. It is still unknown; however, how the morphology of microdamage affects age-related increase in bone fragility. In this study, four-point bending fatigue tests were conducted on aging human bone (age 26 to 89) in conjunction with histological evaluation of the resultant tensile (diffuse damage) and compressive (linear microcracks) damage to identify the damage morphologies associated with an increase in age-related bone fragility. The results demonstrate that young donors (38 ± 9 years) had a longer fatigue life (
P < 0.05) and formed more diffuse damage than the older donors (82 ± 5 years) (
P < 0.05). In contrast, old donors had a shorter fatigue life and formed more linear microcracks than the younger donors (
P < 0.05). Linear microcracks were longer in older than in younger donors (
P < 0.05) and were associated with weak lamellar interfaces. Areas of diffuse damage were, however, larger in younger than in older donors (
P < 0.05), and these showed no relationship with the lamellar arrangement of bone. These findings show, for the first time, that the propensity of bone to form a particular damage morphology is subject to change with age and that the propensity of young donors to form diffuse damage over interlamellae linear microcracks plays a critical role in the ability of bone to dissipate energy and resist a catastrophic fracture. Age-related changes in damage morphology may therefore be an important contributor to the increased bone fragility in the elderly.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16260195</pmid><doi>10.1016/j.bone.2005.09.002</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8756-3282 |
| ispartof | Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.427-431 |
| issn | 8756-3282 1873-2763 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67686135 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age Factors Aged Aged, 80 and over Aging Aging - physiology Bending fatigue Biological and medical sciences Bone and Bones - injuries Bone and Bones - pathology Bone and Bones - physiopathology Bone Density Bone Development Bone Remodeling Compressive Strength Cortical bone Diffuse damage Fractures, Stress Fundamental and applied biological sciences. Psychology Humans Microcracks Microscopy, Confocal Middle Aged Stress, Mechanical Tensile Strength Tibia - injuries Tibia - pathology Tibia - physiopathology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Age-related change in the damage morphology of human cortical bone and its role in bone fragility |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T23%3A50%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-related%20change%20in%20the%20damage%20morphology%20of%20human%20cortical%20bone%20and%20its%20role%20in%20bone%20fragility&rft.jtitle=Bone%20(New%20York,%20N.Y.)&rft.au=Diab,%20Tamim&rft.date=2006-03-01&rft.volume=38&rft.issue=3&rft.spage=427&rft.epage=431&rft.pages=427-431&rft.issn=8756-3282&rft.eissn=1873-2763&rft_id=info:doi/10.1016/j.bone.2005.09.002&rft_dat=%3Cproquest_cross%3E67686135%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17108251&rft_id=info:pmid/16260195&rft_els_id=S8756328205003789&rfr_iscdi=true |