Age-related change in the damage morphology of human cortical bone and its role in bone fragility

Application of cyclic loading results in the formation of distinct strain-dependent microdamage morphologies. It is still unknown; however, how the morphology of microdamage affects age-related increase in bone fragility. In this study, four-point bending fatigue tests were conducted on aging human...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2006-03, Vol.38 (3), p.427-431
Hauptverfasser:	Diab, Tamim, Condon, Keith W., Burr, David B., Vashishth, Deepak
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Aging Aging - physiology Bending fatigue Biological and medical sciences Bone and Bones - injuries Bone and Bones - pathology Bone and Bones - physiopathology Bone Density Bone Development Bone Remodeling Compressive Strength Cortical bone Diffuse damage Fractures, Stress Fundamental and applied biological sciences. Psychology Humans Microcracks Microscopy, Confocal Middle Aged Stress, Mechanical Tensile Strength Tibia - injuries Tibia - pathology Tibia - physiopathology Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	Application of cyclic loading results in the formation of distinct strain-dependent microdamage morphologies. It is still unknown; however, how the morphology of microdamage affects age-related increase in bone fragility. In this study, four-point bending fatigue tests were conducted on aging human bone (age 26 to 89) in conjunction with histological evaluation of the resultant tensile (diffuse damage) and compressive (linear microcracks) damage to identify the damage morphologies associated with an increase in age-related bone fragility. The results demonstrate that young donors (38 ± 9 years) had a longer fatigue life ( P
ISSN:	8756-3282 1873-2763
DOI:	10.1016/j.bone.2005.09.002