Antimicrobial principle from Aframomum longifolius

Abstract Antimicrobial activity-directed fractionation of the seeds of AFRAMOMUM LONGIFOLIUS (Zingiberaceae) afforded two new labdane-type diterpenoids, 15-hydroxy-15-methoxylabda-8(17), 12(E)-dien-16-al (aframolin A) (1) and 8β(17)-epoxy-15,15-dimethoxylabd-12(E)-en-16-al (aframolin B) (2), togethe...

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Veröffentlicht in:	Planta medica 2006-02, Vol.72 (2), p.132-135
Hauptverfasser:	Tatsimo, S.J.N, Tane, P, Melissa, J, Sondengam, B.L, Okunji, C.O, Schuster, B.M, Iwu, M.M, Khan, I.A
Format:	Artikel
Sprache:	eng
Schlagworte:	aframolin Aframomum Aframomum longifolius Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology antibacterial properties antifungal properties Biological and medical sciences Candida albicans - drug effects chemical structure Cryptococcus neoformans Cryptococcus neoformans - drug effects Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoids General pharmacology human health Medical sciences medicinal plants Methicillin Resistance Naphthalenes - chemistry Naphthalenes - pharmacology Original Paper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Preparations - chemistry Plant Preparations - pharmacology spectral analysis Spiro Compounds - chemistry Spiro Compounds - pharmacology Staphylococcus aureus Staphylococcus aureus - drug effects stereochemistry Zingiberaceae - chemistry
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Zusammenfassung:	Abstract Antimicrobial activity-directed fractionation of the seeds of AFRAMOMUM LONGIFOLIUS (Zingiberaceae) afforded two new labdane-type diterpenoids, 15-hydroxy-15-methoxylabda-8(17), 12(E)-dien-16-al (aframolin A) (1) and 8β(17)-epoxy-15,15-dimethoxylabd-12(E)-en-16-al (aframolin B) (2), together with the known diterpenes labda-8(17),12(E)-diene-15,16-dial (3) and aframodial (4). Their structures were determined by spectroscopic methods. Compound 4 showed significant antimicrobial activity against CRYPTOCOCCUS NEOFORMANS, STAPHYLOCOCCUS AUREUS and methicillin-resistant S. AUREUS (MRS) while 1, 2 and 3 were found to be inactive.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2005-873192