A Chemogenomic Approach to Discovering Target-Selective Drugs

A Chemogenomic Approach to Discovering Target-Selective Drugs

An approach is described for identifying scaffolds with predefined selectivity profiles directly from a high‐quality high‐throughput screening data set, and monitoring that selectivity profile throughout the drug discovery process. This approach results in reduced drug development timelines from ‘hi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical biology & drug design 2006-01, Vol.67 (1), p.85-86
Hauptverfasser: Janzen, William P., Hodge, C. Nicholas
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry, Pharmaceutical - methods
Databases, Protein
Drug Design
Structure-Activity Relationship
Technology, Pharmaceutical
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An approach is described for identifying scaffolds with predefined selectivity profiles directly from a high‐quality high‐throughput screening data set, and monitoring that selectivity profile throughout the drug discovery process. This approach results in reduced drug development timelines from ‘hit’ to ‘lead’ stage, and should reduce liabilities for a molecule advancing through the development process.
ISSN:1747-0277
1747-0285
DOI:10.1111/j.1747-0285.2005.00325.x