Association of Kidney Function With Residual Hypertension After Treatment of Aldosterone-Producing Adenoma

Background Autonomous secretion of aldosterone in patients with primary aldosteronism increases glomerular filtration rate and causes kidney damage. The influence of a mild decrease in kidney function on residual hypertension after adrenalectomy is unexplored. Study Design Nonconcurrent prospective...

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Veröffentlicht in:	American journal of kidney diseases 2009-10, Vol.54 (4), p.665-673
Hauptverfasser:	Wu, Vin-Cent, MD, Chueh, Shih-Chieh, MD, PhD, Chang, Hung-Wei, MD, PhD, Lin, Lian-Yu, MD, PhD, Liu, Kao-Lang, MD, Lin, Yen-Hung, MD, Ho, Yi-Luwn, MD, PhD, Lin, Wei-Chou, MD, Wang, Shuo-Meng, MD, Huang, Kuo-How, MD, Hung, Kuan-Yu, MD, PhD, Kao, Tze-Wah, MD, Lin, Shuei-Liong, MD, PhD, Yen, Ruoh-Fang, MD, PhD, Chen, Yung-Ming, MD, Hsieh, Bor-Sen, MD, PhD, Wu, Kwan-Dun, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - blood Adenoma - complications Adenoma - physiopathology Adenoma - secretion Adenoma - surgery Adrenal Cortex Neoplasms - blood Adrenal Cortex Neoplasms - complications Adrenal Cortex Neoplasms - physiopathology Adrenal Cortex Neoplasms - secretion Adrenal Cortex Neoplasms - surgery Adrenalectomy Adult Aldosterone - blood Aldosterone - secretion Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Cardiology. Vascular system Creatinine - blood Female Glomerular Filtration Rate Humans Hyperaldosteronism - blood Hyperaldosteronism - etiology Hyperaldosteronism - metabolism Hyperaldosteronism - physiopathology Hypertension - blood Hypertension - etiology Hypertension - metabolism Hypertension - physiopathology Kidney - metabolism Kidney - physiopathology Kidney Function Tests Male Medical sciences Middle Aged Nephrology Nephrology. Urinary tract diseases Odds Ratio Primary aldosteronism residual hypertension Retrospective Studies Severity of Illness Index
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Zusammenfassung:	Background Autonomous secretion of aldosterone in patients with primary aldosteronism increases glomerular filtration rate and causes kidney damage. The influence of a mild decrease in kidney function on residual hypertension after adrenalectomy is unexplored. Study Design Nonconcurrent prospective study. Setting & Participants The study was based on the Taiwan Primary Aldosteronism Investigation (TAIPAI) database. 150 patients (61 men; overall mean age, 47.2 ± 11.6 years) with a diagnosis of aldosterone-producing adenoma had undergone unilateral adrenalectomy at National Taiwan University Hospital from July 1999 to January 2007. Predictor Presurgery estimated glomerular filtration rate (eGFR). Outcomes & Measurements Residual hypertension after adrenalectomy, defined either as less than 75% of recorded blood pressure measurements with systolic blood pressure less than 140 mm Hg and diastolic blood pressure less than 90 mm Hg or requiring antihypertensive medications during the first year after surgery. Results Before surgery, 27 (18%), 72 (48%), and 51 (34%) patients had moderately to severely decreased (
ISSN:	0272-6386 1523-6838
DOI:	10.1053/j.ajkd.2009.06.014