The Curious Case of Bivalent Marks

The Curious Case of Bivalent Marks

Bivalently marked chromatin, containing both histone H3 lysine 4 (H3K4) and H3K27 trimethylation, is a hallmark of developmentally regulated paused promoters in mammalian embryonic stem cells. In this issue of Developmental Cell, Akkers et al. report that Xenopus tropicalis embryos transition throug...

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Veröffentlicht in:Developmental cell 2009-09, Vol.17 (3), p.301-303
Hauptverfasser: Herz, Hans-Martin, Nakanishi, Shima, Shilatifard, Ali
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chromatin - chemistry
Embryonic Stem Cells - cytology
Histones - chemistry
Humans
Lysine - chemistry
Models, Biological
Models, Genetic
Nucleosomes - metabolism
Promoter Regions, Genetic
Protein Structure, Tertiary
Transcription, Genetic
Xenopus - embryology
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Beschreibung
Zusammenfassung:Bivalently marked chromatin, containing both histone H3 lysine 4 (H3K4) and H3K27 trimethylation, is a hallmark of developmentally regulated paused promoters in mammalian embryonic stem cells. In this issue of Developmental Cell, Akkers et al. report that Xenopus tropicalis embryos transition through early development without the requirement for bivalently marked promoters.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2009.08.014