Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome
ObjectivesWomen with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance. Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome (MS). Hence, the aim of our study was to in...
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| Veröffentlicht in: | European journal of endocrinology 2009-10, Vol.161 (4), p.575-582 |
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| container_title | European journal of endocrinology |
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| creator | Wehr, E Pilz, S Schweighofer, N Giuliani, A Kopera, D Pieber, T R Obermayer-Pietsch, B |
| description | ObjectivesWomen with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance. Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome (MS). Hence, the aim of our study was to investigate the association of 25(OH)D levels and the components of the MS in PCOS women.Methods25(OH)D levels were measured by means of ELISA in 206 women affected by PCOS. Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed.ResultsThe prevalence of insufficient 25(OH)D levels ( |
| doi_str_mv | 10.1530/EJE-09-0432 |
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Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome (MS). Hence, the aim of our study was to investigate the association of 25(OH)D levels and the components of the MS in PCOS women.Methods25(OH)D levels were measured by means of ELISA in 206 women affected by PCOS. Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed.ResultsThe prevalence of insufficient 25(OH)D levels (<30 ng/ml) was 72.8% in women with PCOS. PCOS women with the MS had lower 25(OH)D levels than PCOS women without these features (17.3 vs 25.8 ng/ml respectively; P<0.05). In multivariate regression analysis including 25(OH)D, season, body mass index (BMI), and age, 25(OH)D and BMI were independent predictors of homeostatic model assessment-insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI; P<0.05 for all). In binary logistic regression analyses, 25(OH)D (OR 0.86, P=0.019) and BMI (OR 1.28, P<0.001) were independent predictors of the MS in PCOS women. We found significantly negative correlations of 25(OH)D levels with BMI, waist circumference, waist-to-hip ratio, systolic and diastolic blood pressure, fasting and stimulated glucose, area under the glucose response curve, fasting insulin, HOMA-IR, HOMA-β, triglycerides, and quotient total cholesterol/high-density lipoprotein (HDL) and positive correlations of 25(OH)D levels with QUICKI and HDL (P<0.05 for all).ConclusionWe demonstrate that low 25(OH)D levels are associated with features of the MS in PCOS women. Large intervention trials are warranted to evaluate the effect of vitamin D supplementation on metabolic disturbances in PCOS women.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-09-0432</identifier><identifier>PMID: 19628650</identifier><language>eng</language><publisher>Bristol: BioScientifica</publisher><subject>25-Hydroxyvitamin D 2 - blood ; Adolescent ; Adult ; Anthropometry ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Mass Index ; Clinical Study ; Cohort Studies ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose Intolerance - complications ; Hemodynamics - physiology ; Hormones - blood ; Humans ; Insulin - metabolism ; Lipids - blood ; Medical sciences ; Metabolic diseases ; Metabolic Syndrome - complications ; Metabolic Syndrome - metabolism ; Miscellaneous ; Other metabolic disorders ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - metabolism ; Vertebrates: endocrinology ; Vitamin D - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - metabolism ; Young Adult</subject><ispartof>European journal of endocrinology, 2009-10, Vol.161 (4), p.575-582</ispartof><rights>2009 European Society of Endocrinology</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b425t-daaf3b800c21787bc995686ae87758b4127c8cc8abc8d2158038ba8f0d265be93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22044916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19628650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wehr, E</creatorcontrib><creatorcontrib>Pilz, S</creatorcontrib><creatorcontrib>Schweighofer, N</creatorcontrib><creatorcontrib>Giuliani, A</creatorcontrib><creatorcontrib>Kopera, D</creatorcontrib><creatorcontrib>Pieber, T R</creatorcontrib><creatorcontrib>Obermayer-Pietsch, B</creatorcontrib><title>Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>ObjectivesWomen with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance. Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome (MS). Hence, the aim of our study was to investigate the association of 25(OH)D levels and the components of the MS in PCOS women.Methods25(OH)D levels were measured by means of ELISA in 206 women affected by PCOS. Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed.ResultsThe prevalence of insufficient 25(OH)D levels (<30 ng/ml) was 72.8% in women with PCOS. PCOS women with the MS had lower 25(OH)D levels than PCOS women without these features (17.3 vs 25.8 ng/ml respectively; P<0.05). In multivariate regression analysis including 25(OH)D, season, body mass index (BMI), and age, 25(OH)D and BMI were independent predictors of homeostatic model assessment-insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI; P<0.05 for all). In binary logistic regression analyses, 25(OH)D (OR 0.86, P=0.019) and BMI (OR 1.28, P<0.001) were independent predictors of the MS in PCOS women. We found significantly negative correlations of 25(OH)D levels with BMI, waist circumference, waist-to-hip ratio, systolic and diastolic blood pressure, fasting and stimulated glucose, area under the glucose response curve, fasting insulin, HOMA-IR, HOMA-β, triglycerides, and quotient total cholesterol/high-density lipoprotein (HDL) and positive correlations of 25(OH)D levels with QUICKI and HDL (P<0.05 for all).ConclusionWe demonstrate that low 25(OH)D levels are associated with features of the MS in PCOS women. Large intervention trials are warranted to evaluate the effect of vitamin D supplementation on metabolic disturbances in PCOS women.</description><subject>25-Hydroxyvitamin D 2 - blood</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Clinical Study</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Intolerance - complications</subject><subject>Hemodynamics - physiology</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Lipids - blood</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Miscellaneous</subject><subject>Other metabolic disorders</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Vertebrates: endocrinology</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - metabolism</subject><subject>Young Adult</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LxDAQgOEgiq4fJ--Si16kOknTND2Krl8IXhT0VJI0xUjbrJ2s0n9vZBe9ecpAHibhJeSQwRkrcjif388zqDIQOd8gMybKKpMqf9kkM1AgMiFFvkN2Ed8BWJphm-ywSnIlC5iR1wvEYL2OPgw0tPRtWoRPH3Xvh4Ae6RX98vGN9i5qEzpvaeMxLkejB-uQ-oEuQjfZCWO6Cp96nChOQzOG3u2TrVZ36A7W5x55vp4_Xd5mD483d5cXD5kRvIhZo3WbGwVgOStVaWxVFVJJ7VRZFsoIxkurrFXaWNVwVijIldGqhYbLwrgq3yMnq72LMXwsHca692hd1-nBhSXWspSFFKpM8HQF7RgQR9fWi9H36cs1g_qnZJ1K1lDVPyWTPlqvXZreNX92nS6B4zXQaHXXjimJx1_HOQhRMZkcWznjA1rvhuhbb_W_j38DsnCM5w</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Wehr, E</creator><creator>Pilz, S</creator><creator>Schweighofer, N</creator><creator>Giuliani, A</creator><creator>Kopera, D</creator><creator>Pieber, T R</creator><creator>Obermayer-Pietsch, B</creator><general>BioScientifica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome</title><author>Wehr, E ; Pilz, S ; Schweighofer, N ; Giuliani, A ; Kopera, D ; Pieber, T R ; Obermayer-Pietsch, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b425t-daaf3b800c21787bc995686ae87758b4127c8cc8abc8d2158038ba8f0d265be93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>25-Hydroxyvitamin D 2 - blood</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Clinical Study</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Intolerance - complications</topic><topic>Hemodynamics - physiology</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Lipids - blood</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - metabolism</topic><topic>Miscellaneous</topic><topic>Other metabolic disorders</topic><topic>Polycystic Ovary Syndrome - complications</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Vertebrates: endocrinology</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wehr, E</creatorcontrib><creatorcontrib>Pilz, S</creatorcontrib><creatorcontrib>Schweighofer, N</creatorcontrib><creatorcontrib>Giuliani, A</creatorcontrib><creatorcontrib>Kopera, D</creatorcontrib><creatorcontrib>Pieber, T R</creatorcontrib><creatorcontrib>Obermayer-Pietsch, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wehr, E</au><au>Pilz, S</au><au>Schweighofer, N</au><au>Giuliani, A</au><au>Kopera, D</au><au>Pieber, T R</au><au>Obermayer-Pietsch, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>161</volume><issue>4</issue><spage>575</spage><epage>582</epage><pages>575-582</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>ObjectivesWomen with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance. Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome (MS). Hence, the aim of our study was to investigate the association of 25(OH)D levels and the components of the MS in PCOS women.Methods25(OH)D levels were measured by means of ELISA in 206 women affected by PCOS. Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed.ResultsThe prevalence of insufficient 25(OH)D levels (<30 ng/ml) was 72.8% in women with PCOS. PCOS women with the MS had lower 25(OH)D levels than PCOS women without these features (17.3 vs 25.8 ng/ml respectively; P<0.05). In multivariate regression analysis including 25(OH)D, season, body mass index (BMI), and age, 25(OH)D and BMI were independent predictors of homeostatic model assessment-insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI; P<0.05 for all). In binary logistic regression analyses, 25(OH)D (OR 0.86, P=0.019) and BMI (OR 1.28, P<0.001) were independent predictors of the MS in PCOS women. We found significantly negative correlations of 25(OH)D levels with BMI, waist circumference, waist-to-hip ratio, systolic and diastolic blood pressure, fasting and stimulated glucose, area under the glucose response curve, fasting insulin, HOMA-IR, HOMA-β, triglycerides, and quotient total cholesterol/high-density lipoprotein (HDL) and positive correlations of 25(OH)D levels with QUICKI and HDL (P<0.05 for all).ConclusionWe demonstrate that low 25(OH)D levels are associated with features of the MS in PCOS women. Large intervention trials are warranted to evaluate the effect of vitamin D supplementation on metabolic disturbances in PCOS women.</abstract><cop>Bristol</cop><pub>BioScientifica</pub><pmid>19628650</pmid><doi>10.1530/EJE-09-0432</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | 25-Hydroxyvitamin D 2 - blood Adolescent Adult Anthropometry Biological and medical sciences Blood Glucose - metabolism Body Mass Index Clinical Study Cohort Studies Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Endocrinopathies Female Fundamental and applied biological sciences. Psychology Glucose Intolerance - complications Hemodynamics - physiology Hormones - blood Humans Insulin - metabolism Lipids - blood Medical sciences Metabolic diseases Metabolic Syndrome - complications Metabolic Syndrome - metabolism Miscellaneous Other metabolic disorders Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - metabolism Vertebrates: endocrinology Vitamin D - blood Vitamin D Deficiency - complications Vitamin D Deficiency - metabolism Young Adult |
| title | Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome |
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