Ascorbyl Stearate Inhibits Cell Proliferation and Tumor Growth in Human Ovarian Carcinoma Cells by Targeting the PI3K/AKT Pathway
Ascorbyl stearate is a lipophilic, vitamin C derivative with antitumorigenic properties. The molecular mechanism(s) underlying the anticarcinogenic effect of this compound have not been well documented. The effect of ascorbyl stearate was studied in a panel of human ovarian epithelial cancer cells....
Gespeichert in:
Veröffentlicht in: | Anticancer research 2006-01, Vol.26 (1A), p.203-209 |
---|---|
Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Ascorbyl stearate is a lipophilic, vitamin C derivative with antitumorigenic properties. The molecular mechanism(s) underlying
the anticarcinogenic effect of this compound have not been well documented. The effect of ascorbyl stearate was studied in
a panel of human ovarian epithelial cancer cells. Treatment with ascorbyl stearate caused a dose-dependent inhibition of the
cell proliferation. The antiproliferative effect was due to the arrest of cells in the S/G2-M-phase of the cell cycle. Treatment
of OVCAR-3 cells with ascorbyl stearate also inhibited PI3K/AKT activity. The presence of a constitutively active AKT protected
OVCAR-3 cells from the effects of ascorbyl stearate, suggesting that this nutraceutical targets the PI3K/AKT pathway. The
administration of ascorbyl stearate by gavage induced involution of human ovarian carcinoma xenografts in nude mice. These
studies indicate that the antiproliferative effect of ascorbyl stearate on ovarian epithelial cancer cells is associated with
decreased PI3K/AKT activity, and point toward the PI3K/AKT signaling pathway as a target for this drug. |
---|---|
ISSN: | 0250-7005 1791-7530 |