Toll-like receptors and innate immunity

Toll-like receptors (TLRs) are evolutionarily conserved innate receptors expressed in various immune and non-immune cells of the mammalian host. TLRs play a crucial role in defending against pathogenic microbial infection through the induction of inflammatory cytokines and type I interferons. Furthe...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-10, Vol.388 (4), p.621-625
Hauptverfasser:	Kumar, Himanshu, Kawai, Taro, Akira, Shizuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Eukaryota Host-Pathogen Interactions - immunology Humans Immunity, Innate Innate immunity Pattern-recognition receptors Signal Transduction - immunology Toll-like receptor signaling Toll-like receptors Toll-Like Receptors - immunology Viruses
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Beschreibung
Zusammenfassung:	Toll-like receptors (TLRs) are evolutionarily conserved innate receptors expressed in various immune and non-immune cells of the mammalian host. TLRs play a crucial role in defending against pathogenic microbial infection through the induction of inflammatory cytokines and type I interferons. Furthermore, TLRs also play roles in shaping pathogen-specific humoral and cellular adaptive immune responses. In this review, we describe the recent advances in pathogen recognition by TLRs and TLR signaling.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2009.08.062