Ring-Opening Dynamics of Jadomycin A and B and Dalomycin T

Ring-Opening Dynamics of Jadomycin A and B and Dalomycin T

A novel oxazolone ring-opening and interconversion process between the two jadomycin diastereomeric forms has been characterized by NMR spectroscopy. An analogue, dalomycin T, has been isolated for the first time and does not undergo interconversion.

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Veröffentlicht in:Organic letters 2006-02, Vol.8 (4), p.697-700
Hauptverfasser: Syvitski, Ray T, Borissow, Charles N, Graham, Cathy L, Jakeman, David L
Format: Artikel
Sprache:eng
Schlagworte:
Isoquinolines - chemistry
Molecular Structure
Naphthoquinones
Stereoisomerism
Streptomyces - chemistry
Streptomyces - metabolism
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Zusammenfassung:A novel oxazolone ring-opening and interconversion process between the two jadomycin diastereomeric forms has been characterized by NMR spectroscopy. An analogue, dalomycin T, has been isolated for the first time and does not undergo interconversion.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol052814w