Structural Investigation of Cisplatin-Protein Interactions: Selective Platination of His19 in a Cuprozinc Superoxide Dismutase

Structural Investigation of Cisplatin-Protein Interactions: Selective Platination of His19 in a Cuprozinc Superoxide Dismutase

Drug adduct: The X‐ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8‐Å resolution. Selective platination of His19 occurs far away from the copper–zinc site. Remarkably, the protein‐bound platinum center retains both chloro ligands (see...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-02, Vol.45 (8), p.1267-1269
Hauptverfasser: Calderone, Vito, Casini, Angela, Mangani, Stefano, Messori, Luigi, Orioli, Pier Luigi
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - chemistry
antitumor agents
cisplatin
Cisplatin - chemistry
DNA - chemistry
Histidine - chemistry
Models, Molecular
platinum
Protein Conformation
superoxide dismutase
Superoxide Dismutase - chemistry
X-ray diffraction
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Zusammenfassung:Drug adduct: The X‐ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8‐Å resolution. Selective platination of His19 occurs far away from the copper–zinc site. Remarkably, the protein‐bound platinum center retains both chloro ligands (see picture, Cu orange, Zn dark gray, Pt light gray, Cl green).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502599