Dynamic multi-section CT imaging in acute myocardial infarction: preliminary animal experience

To evaluate the feasibility of myocardial first-pass perfusion imaging with multidetector CT (MDCT). In five pigs, myocardial infarction was induced by permanent balloon occlusion of the left anterior descending coronary artery. Dynamic contrast-enhanced MDCT (12x1.5 mm, 120 kV, 30 mAs, 64 acquisiti...

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Veröffentlicht in:European radiology 2006-03, Vol.16 (3), p.746-752
Hauptverfasser: Mahnken, Andreas H, Bruners, Philipp, Katoh, Marcus, Wildberger, Joachim E, Günther, Rolf W, Buecker, Arno
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Sprache:eng
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Zusammenfassung:To evaluate the feasibility of myocardial first-pass perfusion imaging with multidetector CT (MDCT). In five pigs, myocardial infarction was induced by permanent balloon occlusion of the left anterior descending coronary artery. Dynamic contrast-enhanced MDCT (12x1.5 mm, 120 kV, 30 mAs, 64 acquisitions, 40 ml iopromide 370@4 ml/s) and contrast-enhanced first-pass perfusion magnetic resonance (MR) imaging (TR 7.7 ms/TE 2.6 ms, 64 acquisitions, 0.05 mmol/kg Gd-DTPA) were performed. Finally, the animals were sacrificed, and the heart was excised and stained with triphenyltetrazolin-chloride (TTC). Maximum signal intensity (SImax), contrast material arrival time (CAT), wash-in time (Tmax) and slope were calculated from time-density/signal-intensity curves. The area of myocardial hypoperfusion was measured as the percentage of the left-ventricular area (%LV). Parameters were compared using Bland-Altman plots and Student's t-tests. The hypoperfused area on MDCT was 19.3+/-4.5%LV (MR imaging 17.2+/-4.0%LV). The mean size of infarction was 18.7+/-5.7%LV with TTC. Semiquantitative analysis of MR imaging and MDCT for SImax, Tmax and slope showed significant differences between normal and infarcted myocardium (P
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-005-0057-5