Catalytic Promiscuity and the Divergent Evolution of DNA Repair Enzymes

Catalytic Promiscuity and the Divergent Evolution of DNA Repair Enzymes

O'Brien offers an overview of how divergent evolution of DNA repair enzymes is related to a fundamental property of enzymes--catalytic promiscuity.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical reviews 2006-02, Vol.106 (2), p.720-752
1. Verfasser: O'Brien, Patrick J
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Catalysis
Catalytic Domain
Deoxyribonucleic acid
DNA
DNA Damage
DNA Repair
DNA Repair Enzymes - chemistry
DNA Repair Enzymes - genetics
DNA Repair Enzymes - metabolism
Enzymes
Evolution
Evolution, Molecular
Humans
Molecular Sequence Data
Protein Conformation
Protein Engineering
Substrate Specificity
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Beschreibung
Zusammenfassung:O'Brien offers an overview of how divergent evolution of DNA repair enzymes is related to a fundamental property of enzymes--catalytic promiscuity.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr040481v