Influence of number of CAG repeats on local control in the RTOG 86-10 protocol

The number of CAG repeats on the androgen receptor (AR) gene is inversely proportional to transcriptional activity. The purpose of this study was to determine if short-term androgen deprivation therapy (RT + HT) can improve outcome in patients with tumors with short CAG repeats (

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of clinical oncology 2006-02, Vol.29 (1), p.14-20
Hauptverfasser:	Abdel-Wahab, May, Berkey, Brian A, Krishan, Awtar, O'Brien, Tom, Hammond, Elizabeth, Roach, 3rd, Mack, Lawton, Colleen, Pilepich, Milijenko, Markoe, Arnold, Pollack, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - therapeutic use Combined Modality Therapy Flow Cytometry Goserelin - therapeutic use Humans Male Prognosis Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - radiotherapy Receptors, Androgen - genetics Survival Analysis Treatment Outcome Trinucleotide Repeats
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Beschreibung
Zusammenfassung:	The number of CAG repeats on the androgen receptor (AR) gene is inversely proportional to transcriptional activity. The purpose of this study was to determine if short-term androgen deprivation therapy (RT + HT) can improve outcome in patients with tumors with short CAG repeats (
ISSN:	0277-3732 1537-453X
DOI:	10.1097/01.coc.0000195085.34162.88