Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents

Schiff base conjugates of p-aminosalicylic acid containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher ClogP values and superior radical scavenging activities are thought to be the contributing factors for the...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-03, Vol.16 (6), p.1514-1517
Hauptverfasser:	Patole, Jayendra, Shingnapurkar, Dipti, Padhye, Subhash, Ratledge, Colin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminosalicylic Acid - chemical synthesis Aminosalicylic Acid - chemistry Aminosalicylic Acid - pharmacology Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimycobacterial agents Biological and medical sciences Free Radical Scavengers - chemical synthesis Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Mycobacterium bovis Mycobacterium bovis - drug effects Mycobacterium smegmatis Mycobacterium smegmatis - drug effects para-Amino salicyclic acid Pharmacology. Drug treatments Schiff Bases - chemistry Spectrophotometry, Infrared Structure-Activity Relationship
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Zusammenfassung:	Schiff base conjugates of p-aminosalicylic acid containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher ClogP values and superior radical scavenging activities are thought to be the contributing factors for their enhanced antimycobacterial activities. Schiff base conjugates of p-aminosalicylic acid have been synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopy and cyclic voltammetry. Compounds containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher ClogP values and superior radical scavenging activities are thought to be the contributing factors for their enhanced antimycobacterial activities.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.12.035