A 2-Arylbenzofuran Derivative from Hopea Mengarawan

A new 2-arylbenzofuran derivative (diptoindonesin G) (1), along with nine known oligostilbenes, have been isolated and identified from the acetone extract of the tree bark of Hopea mengarawan. The structures of these compounds were determined based on spectroscopic data, including 2D NMR and HREIMS...

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Veröffentlicht in:	Natural product communications 2009-07, Vol.4 (7), p.947-950
Hauptverfasser:	Juliawaty, Lia D., Sahidin, Hakim, Euis H., Achmad, Sjamsul A., Syah, Yana M., Latip, Jalifah, Said, Ikram M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Benzofurans - chemistry Benzofurans - isolation & purification Benzofurans - pharmacology Cell Line, Tumor Dipterocarpaceae - chemistry Drug Screening Assays, Antitumor Leukemia P388 - drug therapy Magnetic Resonance Spectroscopy Mice Plant Bark - chemistry Solvents Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared
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Zusammenfassung:	A new 2-arylbenzofuran derivative (diptoindonesin G) (1), along with nine known oligostilbenes, have been isolated and identified from the acetone extract of the tree bark of Hopea mengarawan. The structures of these compounds were determined based on spectroscopic data, including 2D NMR and HREIMS spectra. On cytotoxic evaluation of the isolated compounds against murin leukemia P-388 cells, compound 1 was the strongest in inhibiting the growth of the cells.
ISSN:	1934-578X 1555-9475
DOI:	10.1177/1934578X0900400715