Oxygen deprivation provokes melanoma
Melanoma may be promoted by low oxygen conditions in the skin, which turn on the oxygen-response regulator HIF-1. HIF-1 seems to act in concert with well-established oncoproteins to promote tumorigenesis—a process that responds to the drug rapamycin.
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| Veröffentlicht in: | Nature medicine 2006-02, Vol.12 (2), p.168-169 |
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| container_title | Nature medicine |
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| creator | Adams, Amy E Chudnovsky, Yakov Khavari, Paul A |
| description | Melanoma may be promoted by low oxygen conditions in the skin, which turn on the oxygen-response regulator HIF-1. HIF-1 seems to act in concert with well-established oncoproteins to promote tumorigenesis—a process that responds to the drug rapamycin. |
| doi_str_mv | 10.1038/nm0206-168 |
| format | Article |
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| ispartof | Nature medicine, 2006-02, Vol.12 (2), p.168-169 |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell Transformation, Neoplastic Humans Hypoxia - complications Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Infectious Diseases Melanoma Melanoma - etiology Melanoma - metabolism Metabolic Diseases Mice Molecular Medicine Neurosciences news-and-views Oncogene Protein v-akt - metabolism Oxygen Phosphatidylinositol 3-Kinases - metabolism Proteins Skin cancer Skin Neoplasms - etiology Skin Neoplasms - metabolism Tumors |
| title | Oxygen deprivation provokes melanoma |
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