Oxygen deprivation provokes melanoma

Melanoma may be promoted by low oxygen conditions in the skin, which turn on the oxygen-response regulator HIF-1. HIF-1 seems to act in concert with well-established oncoproteins to promote tumorigenesis—a process that responds to the drug rapamycin.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2006-02, Vol.12 (2), p.168-169
Hauptverfasser:	Adams, Amy E, Chudnovsky, Yakov, Khavari, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell Transformation, Neoplastic Humans Hypoxia - complications Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Infectious Diseases Melanoma Melanoma - etiology Melanoma - metabolism Metabolic Diseases Mice Molecular Medicine Neurosciences news-and-views Oncogene Protein v-akt - metabolism Oxygen Phosphatidylinositol 3-Kinases - metabolism Proteins Skin cancer Skin Neoplasms - etiology Skin Neoplasms - metabolism Tumors
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Beschreibung
Zusammenfassung:	Melanoma may be promoted by low oxygen conditions in the skin, which turn on the oxygen-response regulator HIF-1. HIF-1 seems to act in concert with well-established oncoproteins to promote tumorigenesis—a process that responds to the drug rapamycin.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm0206-168