Transcription promotes contraction of CAG repeat tracts in human cells

Induced transcription through CAG repeats in human cells increases repeat contraction ∼15-fold in both confluent and proliferating cells. Repeats are stabilized against contraction by siRNA knockdown of MSH2, MSH3 or XPA, but not by knockdown of MSH6, XPC or FEN1. These results define a pathway for...

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Veröffentlicht in:	Nature structural & molecular biology 2006-02, Vol.13 (2), p.179-180
Hauptverfasser:	Lin, Yunfu, Dion, Vincent, Wilson, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biochemistry Biological Microscopy Biomedical and Life Sciences brief-communication Cell Line, Tumor Cell proliferation Deoxyribonucleic acid DNA DNA binding proteins DNA repair Genetic transcription Humans Life Sciences Membrane Biology Molecular biology Physiological aspects Protein Structure RNA, Small Interfering - genetics Sequence Deletion - genetics Structure Transcription, Genetic - genetics Trinucleotide Repeats - genetics
Online-Zugang:	Volltext
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