Cytotoxic Polyprenylated Xanthones from the Resin of Garcinia hanburyi

Thirteen xanthones (1—13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2006, Vol.54(2), pp.265-267
Hauptverfasser:	Han, Quan-Bin, Wang, Yu-Lin, Yang, Ling, Tso, Ting-Fai, Qiao, Chun-Feng, Song, Jing-Zheng, Xu, Li-Jia, Chen, Shi-Lin, Yang, Da-Jian, Xu, Hong-Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Cell Line, Tumor cytotoxicity Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics Garcinia - chemistry Garcinia hanburyi gaudichaudic acid Humans isogambogenic acid K562 Cells multidrug resistance Protein Prenylation Resins, Plant - chemistry Spectrometry, Mass, Electrospray Ionization xanthone Xanthones - isolation & purification Xanthones - pharmacology
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Zusammenfassung:	Thirteen xanthones (1—13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.54.265