The origin of epithelial neoplasms after allogeneic stem cell transplantation

We analyzed five women, who have developed epithelial neoplasms after sex-mismatched stem cell transplants. Using in situ hybridization for sex chromosome-specific DNA probes and immunohistochemistry we identified the origin of the tumor cells. We conclude that none of the non-hematologic malignanci...

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Veröffentlicht in:	Haematologica (Roma) 2006-02, Vol.91 (2), p.283-284
Hauptverfasser:	Smith, MJ, van Cleef, PH, Schattenberg, AV, van Krieken, JH
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Female Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - adverse effects Humans Medical sciences Middle Aged Neoplasms, Glandular and Epithelial - etiology Neoplasms, Glandular and Epithelial - pathology Tissue Donors Transplantation, Homologous
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Zusammenfassung:	We analyzed five women, who have developed epithelial neoplasms after sex-mismatched stem cell transplants. Using in situ hybridization for sex chromosome-specific DNA probes and immunohistochemistry we identified the origin of the tumor cells. We conclude that none of the non-hematologic malignancies was of donor origin.
ISSN:	0390-6078 1592-8721