Carbon Nanotube Delivery of the GFP Gene into Mammalian Cells

Special delivery. Amino‐functionalized multiwalled carbon nanotubes (NH2‐MWCNTs) were found to interact with negatively charged DNA and the cell membrane (see figure). Through this interaction, NH2‐MWCNTs successfully delivered the GFP (green fluorescent protein) gene into mammalian cells without an...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2006-02, Vol.7 (2), p.239-242
Hauptverfasser:	Gao, Lizeng, Nie, Leng, Wang, Taihong, Qin, Yujun, Guo, Zhixin, Yang, Dongling, Yan, Xiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line gene expression gene technology Gene Transfer Techniques green fluorescent protein Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Nanotechnology nanotubes Nanotubes, Carbon - chemistry Nanotubes, Carbon - ultrastructure Plasmids - genetics Plasmids - metabolism
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Beschreibung
Zusammenfassung:	Special delivery. Amino‐functionalized multiwalled carbon nanotubes (NH2‐MWCNTs) were found to interact with negatively charged DNA and the cell membrane (see figure). Through this interaction, NH2‐MWCNTs successfully delivered the GFP (green fluorescent protein) gene into mammalian cells without any cytotoxicity. The results show that NH2‐MWCNT is a novel gene carrier and has potential application in gene delivery.
ISSN:	1439-4227 1439-7633 1439-4227
DOI:	10.1002/cbic.200500227