Dose-dependent cholesterol-lowering effect of a mayonnaise-type product with a main component of diacylglycerol-containing plant sterol esters

The objective of this study was to investigate the effective dose of plant sterol ester (PSE)-enriched diacylglycerol (DAG) oil for healthy subjects with mild hypercholesterolemia. A randomized, placebo-controlled, double-blind, parallel study was performed in patients with mild hypercholesterolemia...

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Veröffentlicht in:	Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2006-02, Vol.22 (2), p.174-178
Hauptverfasser:	Saito, Shinichiro, Takeshita, Masao, Tomonobu, Kazuichi, Kudo, Naoto, Shiiba, Daisuke, Hase, Tadashi, Tokimitsu, Ichiro, Yasukawa, Takuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - therapeutic use Biological and medical sciences blood lipids cholesteremic effect Cholesterol Cholesterol - blood cholesterol metabolism Cholesterol, HDL - blood Cholesterol, LDL - blood cholesteryl esters Diacylglycerol diacylglycerols Diet Diglycerides - therapeutic use Dose-Response Relationship, Drug Double-Blind Method Esters Feeding. Feeding behavior food intake Fundamental and applied biological sciences. Psychology high density lipoprotein Humans hypercholesterolemia Hypercholesterolemia - diet therapy Ingestion Low density lipoprotein Male Mayonnaise men phytosterols Phytosterols - therapeutic use Plant sterol esters Studies Treatment Outcome Triacylglycerol triacylglycerols Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Beschreibung
Zusammenfassung:	The objective of this study was to investigate the effective dose of plant sterol ester (PSE)-enriched diacylglycerol (DAG) oil for healthy subjects with mild hypercholesterolemia. A randomized, placebo-controlled, double-blind, parallel study was performed in patients with mild hypercholesterolemia; 0.0, 0.3, 0.4, and 0.5 g of PSE was dissolved in 15 g of a DAG-containing mayonnaise-type product; and 15 g/d of the product was administered 4 wk. Total serum cholesterol levels were significantly decreased as a result of the ingestion of at least 0.4 g/d of PSE, and serum low-density lipoprotein cholesterol levels were significantly decreased by the ingestion of at least 0.3 g/d of PSE. Daily ingestion of 15 g of DAG plus mayonnaise containing at least 0.4 g/d of PSE for 4 wk may significantly decrease cholesterol.
ISSN:	0899-9007 1873-1244
DOI:	10.1016/j.nut.2005.05.013