The frequency of neuroendocrine cell hyperplasia in patients with pulmonary neuroendocrine tumours and non-neuroendocrine cell carcinomas

Aims: To evaluate the frequency of neuroendocrine cell hyperplasia (NEH) in resected neuroendocrine tumours and non‐neuroendocrine cell carcinomas and to study its relationship to selected clinical parameters. Methods and results: Random blocks without tumour from resected typical carcinoids (TCs,...

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Veröffentlicht in:	Histopathology 2009-09, Vol.55 (3), p.332-337
Hauptverfasser:	Rizvi, Selim M H, Goodwill, Joseph, Lim, Eric, Yap, Yoong K, Wells, Athol U, Hansell, David M, Davis, Peter, Abdel-Ghani, Syed, Goldstraw, Peter, Nicholson, Andrew G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - surgery Adult Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoid Tumor - metabolism Carcinoid Tumor - pathology Carcinoid Tumor - surgery Carcinoma, Small Cell - metabolism Carcinoma, Small Cell - pathology Carcinoma, Small Cell - surgery Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery CD56 Antigen - metabolism Cell Proliferation Female Humans Hyperplasia Investigative techniques, diagnostic techniques (general aspects) Lung - pathology Lung - physiopathology Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - surgery Male Medical sciences Middle Aged neuroendocrine cell hyperplasia Neuroendocrine Cells - metabolism Neuroendocrine Cells - pathology neuroendocrine tumours non-neuroendocrine cell carcinomas Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Precancerous Conditions Respiratory Function Tests Young Adult
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Zusammenfassung:	Aims: To evaluate the frequency of neuroendocrine cell hyperplasia (NEH) in resected neuroendocrine tumours and non‐neuroendocrine cell carcinomas and to study its relationship to selected clinical parameters. Methods and results: Random blocks without tumour from resected typical carcinoids (TCs, n = 46), atypical carcinoids (ACs, n = 14), large cell neuroendocrine carcinomas (LCNECs, n = 18), small cell carcinomas (SCLCs, n = 22), adenocarcinomas (ADENOs, n = 26) and squamous cell carcinomas (SCCs, n = 18) were stained for CD56 and evaluated for linear proliferations, cell aggregates (>4 CD56+ cells), and tumourlets (
ISSN:	0309-0167 1365-2559
DOI:	10.1111/j.1365-2559.2009.03371.x