Platelets might mediate the increase of plasma glutamate in acute ischemic stroke: Relevance for early neurological deterioration

Summary In this brief paper we would like to hypothesize that platelets might represent a “peripheral” contributory source for the elevation of plasma glutamate levels in the setting of acute ischemic stroke: available evidence and possible mechanisms will be discussed, especially drawing attention to the possible relevance for the pathophysiology of early neurological deterioration.