Poststroke Epilepsy in the Copenhagen Stroke Study: Incidence and Predictors

Poststroke epilepsy (PSE) is a feared complication after stroke and is reported in 3% to 5% of stroke survivors. In this study we sought to identify incidence and predictors of PSE in an unselected stroke population with a follow-up period of 7 years. The study was community-based and comprises a cohort of 1197 consecutively and prospectively admitted patients with stroke. Patients were followed up for 7 years. We defined PSE as recurrent epileptic seizures with onset after stroke and requiring antiepileptic prophylaxis. PSE was related to clinical factors (age, sex, onset stroke severity, lesion size on computed tomography scans, stroke subtype, localization, stroke risk factor profile, and early seizures) in univariate analyses. Independent predictors of PSE were identified through multiple logistic regression analyses. Overall, 38 patients (3.2%) developed PSE. Univariately, PSE was associated with younger age, intracerebral hemorrhage, and larger lesions. PSE was less frequently associated with atrial fibrillation and ischemic heart disease. In the final multiple regression model for the dependent variable PSE, independent predictors were younger age (odds ratio [OR] 1.7/10 years; 95% confidence interval [CI] 1.3-2.1), onset stroke severity (OR 1.3-/10-point decrease; 95% CI 1.0-1.6), lesion size (OR 1.2-/10-mm enlargement; 95% CI 1.0-1.3), intracerebral hemorrhage (OR 3.3; 95% CI 1.3-8.6), and early seizures (OR 4.5; 95% CI 1.3-16.0). We conclude that PSE occurs in about 3% of all patients with stroke within 7 years after stroke. Age, intracerebral hemorrhage, lesion size, increasing stroke severity, and early seizures are independent predictors of PSE.