Fe‐Catalyzed Oxidative Coupling of Heteroarenes and Methylamines

New way to benzylic amines! Fe‐catalyzed oxidative cross‐coupling of electron‐rich heteroarenes and methylamines is established. Under the influence of FeCl2/bipy catalyst and oxidant (pyridine N‐oxide or H2O2), thiophenes, furans, indoles, and azaindoles cross‐couple with methylamines to furnish th...

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Veröffentlicht in:	Chemistry, an Asian journal an Asian journal, 2009-09, Vol.4 (9), p.1416-1419
Hauptverfasser:	Ohta, Masaki, Quick, Matthias P., Yamaguchi, Junichiro, Wünsch, Bernhard, Itami, Kenichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis cross‐coupling CH functionalization heterocycles Heterocyclic Compounds - chemistry iron Iron - chemistry Methylamines - chemistry oxidation Oxidation-Reduction
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Beschreibung
Zusammenfassung:	New way to benzylic amines! Fe‐catalyzed oxidative cross‐coupling of electron‐rich heteroarenes and methylamines is established. Under the influence of FeCl2/bipy catalyst and oxidant (pyridine N‐oxide or H2O2), thiophenes, furans, indoles, and azaindoles cross‐couple with methylamines to furnish the corresponding benzylic amines. An intramolecular CH/CH coupling of a thiophene is observed to afford a good ligand for the σ1 receptor protein.
ISSN:	1861-4728 1861-471X
DOI:	10.1002/asia.200900157