Synthesis and properties of 2′- O,4′- C-methyleneoxymethylene bridged nucleic acid

A novel bridged nucleic acid (BNA) analogue, 2′- O,4′- C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNA COC), was synthesized and incorporated into oligonucleotides. The 2′,4′-BNA COC modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stabi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-02, Vol.14 (4), p.1029-1038
Hauptverfasser:	Hari, Yoshiyuki, Obika, Satoshi, Ohnishi, Ryo, Eguchi, Ken, Osaki, Tomohisa, Ohishi, Hirofumi, Imanishi, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bridged nucleic acids Conformation Crystallography, X-Ray Heterocyclic Compounds - chemistry Medical sciences Miscellaneous Molecular Structure Nucleic Acid Denaturation Nucleic Acids - chemical synthesis Nucleic Acids - chemistry Nucleic Acids - metabolism Nucleosides Oligonucleotides Pharmacology. Drug treatments Phosphodiesterase I - metabolism Snakes Temperature
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Zusammenfassung:	A novel bridged nucleic acid (BNA) analogue, 2′- O,4′- C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNA COC), was synthesized and incorporated into oligonucleotides. The 2′,4′-BNA COC modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stability against snake venom phosphodiesterase.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2005.09.020