Effect of polycyclic cage amines on the transmembrane potential of neuronal cells

Pentacycloundecylamine derivatives influence the profile of KCl-induced membrane depolarization and cause an overall reduction in cell membrane depolarization. A series of pentacycloundecylamine derivatives were synthesized and their influence on the transmembrane potential of human SH-SY5Y neuroblastoma cells was evaluated using laser scanning confocal microscopy in combination with the potentiometric dye tetramethylrhodamine methyl ester. Results indicate that these derivatives influence the profile of KCl-induced membrane depolarization and cause an overall reduction in cell membrane depolarization.