Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice

Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and T cells and IL-17 may connect innate and adaptive immune responses involved in atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and transplanted LDLr deficient recipient mi...

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Veröffentlicht in:Biochemical and biophysical research communications 2009-10, Vol.388 (2), p.261-265
Hauptverfasser: van Es, T., van Puijvelde, G.H.M., Ramos, O.H., Segers, F.M.E., Joosten, L.A., van den Berg, W.B., Michon, I.M., de Vos, P., van Berkel, Th.J.C., Kuiper, J.
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Sprache:eng
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Zusammenfassung:Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and T cells and IL-17 may connect innate and adaptive immune responses involved in atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and transplanted LDLr deficient recipient mice with IL-17R deficient bone marrow. Induction of atherosclerosis by Western-type diet induced a 46% reduction in lesion size in the aortic root and the plaque composition revealed no significant changes in collagen content and neutrophil counts, but a reduction in mast cell number and an increase in macrophage number. In addition, we observed a decrease in anti-oxLDL antibodies of the IgG class upon IL-17R BMT, while introduction of IL-17R deficient bone marrow resulted in a reduced IL-6 production and an increased IL-10 production. In conclusion, signaling via the IL-17 receptor in bone marrow derived cells enhances the process of atherosclerosis.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2009.07.152