Autologous peripheral blood stem cell transplantation for POEMS syndrome

Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and auto...

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Veröffentlicht in:	Neurology 2006-01, Vol.66 (1), p.105-107
Hauptverfasser:	Kuwabara, S, Misawa, S, Kanai, K, Kikkawa, Y, Nishimura, M, Nakaseko, C, Cho, R K, Hattori, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Down-Regulation - drug effects Down-Regulation - physiology Female Hematopoietic Stem Cell Transplantation - methods Humans Male Melphalan - therapeutic use Middle Aged Myeloablative Agonists - therapeutic use Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - etiology Peripheral Nervous System Diseases - physiopathology Plasmacytoma - complications Plasmacytoma - drug therapy Plasmacytoma - metabolism POEMS Syndrome - physiopathology POEMS Syndrome - therapy Transplantation, Autologous Treatment Outcome Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - secretion
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Zusammenfassung:	Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.wnl.0000188757.38495.23